Kitporntheranunt Maethaphan, Manolertthewan Wichian
J Med Assoc Thai. 2016 Nov;99 Suppl 8:S196-S200.
Cystatin C is a biomarker of renal function and other diseases. Physiologic changes during pregnancy can alter it level and lead to misinterpretation of result.
To determine reference values for serum cystatin C in the first trimester of pregnancy.
The Thai singleton uncomplicated pregnant women who attend antenatal clinic at Maha Chakri Sirindhorn Medical Center during August 2013 to December 2014 were included. Gestational age of individual was calculated by last menstrual period or ultrasound scan. Demographic data and obstetrics outcomes were recorded. Peripheral blood was taken on the first prenatal visit. Serum cystatin C was measured by particle-enhanced turbidimetric immunoassay (PETIA) with ARCHITECT c Systems® (ABBOTT, Germany).
A total of 48 pregnant women were eligible for the study. The overall mean and standard deviation of serum cystatin C was 0.58+0.08 mg/L. There was no significant correlation between serum cystatin C and creatinine level (r = 0.22, p-value = 0.13).
The reference value of serum cystatin C was established for Thai pregnant women in the first trimester. Further studies of its correlation to specific obstetrics conditions should be considered.
胱抑素C是肾功能及其他疾病的生物标志物。孕期的生理变化会改变其水平并导致结果解读错误。
确定妊娠早期血清胱抑素C的参考值。
纳入2013年8月至2014年12月期间在玛哈·扎克里·诗琳通医疗中心产前门诊就诊的泰国单胎无并发症孕妇。通过末次月经或超声扫描计算个体的孕周。记录人口统计学数据和产科结局。在首次产前检查时采集外周血。采用ARCHITECT c Systems®（德国雅培公司）的颗粒增强比浊免疫分析法（PETIA）测定血清胱抑素C。
共有48名孕妇符合研究条件。血清胱抑素C的总体均值和标准差为0.58±0.08 mg/L。血清胱抑素C与肌酐水平之间无显著相关性（r = 0.22，p值 = 0.13）。
确立了泰国孕妇妊娠早期血清胱抑素C的参考值。应考虑进一步研究其与特定产科情况的相关性。
