阿尔法万能：小岛守护者。
Alpha the versatile: Guardians of the islets.
机构信息
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
出版信息
J Diabetes Investig. 2019 Jan;10(1):26-28. doi: 10.1111/jdi.12875. Epub 2018 Jul 25.
Abstract
Recent progress in α-cell research has newly revealed its versatility including secretion of multiple hormones, trans-differentiation, and abundant proliferation. A recent report from the Kushner laboratory further provided direct evidence of active proliferation of α-cells in both T1D and non-diabetic control donors. α-cells are suggested to maintain both quality and quantity of islets by serving as 'guardians' of the islets.
摘要
近年来，α 细胞研究的进展揭示了其多功能性，包括分泌多种激素、转分化和丰富的增殖。最近 Kushner 实验室的一份报告进一步提供了直接证据，证明 T1D 和非糖尿病对照供体中的 α 细胞存在活跃增殖。α 细胞被认为通过充当胰岛的“守护者”来维持胰岛的质量和数量。
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