肢端黑素瘤的 Breslow 厚度与皮肤镜表现的相关性。

Association between Breslow thickness and dermoscopic findings in acral melanoma.

机构信息

Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul, South Korea.

Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea.

出版信息

J Am Acad Dermatol. 2018 Nov;79(5):831-835. doi: 10.1016/j.jaad.2018.06.004. Epub 2018 Jun 13.

DOI:10.1016/j.jaad.2018.06.004

PMID:29906546

Abstract

BACKGROUND

Dermoscopy is a useful tool for the diagnosis of acral melanomas (AMs). However, little is known about the influence of tumor thickness on the dermoscopic findings of AM.

OBJECTIVE

To investigate the affect Breslow thickness (BT) has on the dermoscopic patterns of AM.

METHODS

Data on cases of AM on the glabrous skin were collected from 4 university hospitals. We investigated the frequency of each dermoscopic feature of AM according to the BT. Statistical analysis was performed to investigate the association between the specific dermoscopic patterns and BT.

RESULTS

Multivariable analysis revealed that the colors red (odds ratio [OR] 16.482, 95% confidence interval [CI] 3.605-99.016); blue (OR 7.092; 95% CI 1.707-37.435); and white (OR 5.048, 95% CI 1.152-22.897) were more common in AM with BT >2 mm than those with BT ≤2 mm. Regarding patterns, atypical vascular (OR 34.589, 95% CI 6.458-305.852); blue-white veils (OR 9.605, 95% CI 1.971-72.062); and ulcers (OR 5.084, 95% CI 1.145-24.152) were more frequently detected in cases with BT >2 mm than those with BT ≤2 mm.

LIMITATIONS

A retrospective study design and small sample size.

CONCLUSION

This study showed an association between dermoscopic patterns and tumor thickness among patients with AM. Dermoscopy can be a useful adjuvant tool for predicting BT in AM.

摘要

背景

皮肤镜检查是诊断肢端黑素瘤（AM）的有用工具。然而，对于肿瘤厚度对 AM 皮肤镜表现的影响知之甚少。

目的

探讨 Breslow 厚度（BT）对 AM 皮肤镜模式的影响。

方法

从 4 所大学医院收集了无毛发皮肤 AM 病例的数据。我们根据 BT 调查了 AM 每个皮肤镜特征的频率。进行了统计分析以研究特定皮肤镜模式与 BT 之间的关联。

结果

多变量分析显示，颜色红色（优势比 [OR] 16.482，95%置信区间 [CI] 3.605-99.016）；蓝色（OR 7.092；95% CI 1.707-37.435）；白色（OR 5.048，95% CI 1.152-22.897）在 BT>2mm 的 AM 中比 BT≤2mm 的 AM 更常见。关于模式，非典型血管（OR 34.589，95% CI 6.458-305.852）；蓝白面纱（OR 9.605，95% CI 1.971-72.062）；和溃疡（OR 5.084，95% CI 1.145-24.152）在 BT>2mm 的病例中比 BT≤2mm 的病例更频繁地发现。