Genazzani A R, Petraglia F, Volpe A, Facchinetti F
Cephalalgia. 1985 May;5 Suppl 2:212-4.
The effects exerted by ovarian steroids on the modulation of opioid activity were investigated in post-menopausal migraine sufferers and in healthy controls. In order to evaluate central opioid tonus, plasma LH rise after naloxone injection was measured, bearing in mind the tonic inhibition of endogenous opioid on hypothalamic LH-RH. There was no response of plasma LH to naloxone in post-menopausal women or in patients submitted to ovariectomy in fertile life. When the subjects underwent a sequential estrogens + progestagens therapy, such a response was noted from the first month of treatment; progestagens alone were ineffective. The same phenomena were also evident in post-menopausal migraine sufferers. These data indicate that ovarian steroids modulate the activity of opiate receptors in both healthy women and migraine sufferers. Interestingly, replacement therapies through ovarian steroids restored the activity of central opioid tonus in patients affected by migraine.
在绝经后偏头痛患者和健康对照者中研究了卵巢甾体激素对阿片类活性调节的影响。为了评估中枢阿片类张力，测量了纳洛酮注射后血浆促黄体生成素（LH）的升高，同时考虑到内源性阿片类对下丘脑促性腺激素释放激素（LH-RH）的紧张性抑制作用。绝经后妇女或育龄期接受卵巢切除术的患者血浆LH对纳洛酮无反应。当受试者接受序贯雌激素+孕激素治疗时，从治疗的第一个月就观察到了这种反应；单独使用孕激素无效。同样的现象在绝经后偏头痛患者中也很明显。这些数据表明，卵巢甾体激素在健康女性和偏头痛患者中均调节阿片受体的活性。有趣的是，通过卵巢甾体激素的替代疗法恢复了偏头痛患者中枢阿片类张力的活性。
