Petraglia F, Martignoni E, Sola D, Cicoli C, Facchinetti F, Nappi G, Genazzani A R
Cephalalgia. 1983 Aug;3 Suppl 1:98-100. doi: 10.1177/03331024830030S114.
The aim of this study is to make an evaluation of the activity of endogenous opioid tonus in patients affected by menstrual migraine. We tested the LH response to naloxone injection, an opiate receptor antagonist, in 18 migraineurs in the early and late luteal periods going towards the attacks. The lack of any response in the latter group demonstrates an opioid disregulation in this kind of pathology.
本研究的目的是评估月经性偏头痛患者内源性阿片张力的活性。我们对18名在黄体期早期和晚期即将发作时的偏头痛患者注射阿片受体拮抗剂纳洛酮后促黄体生成素（LH）的反应进行了测试。后一组患者缺乏任何反应，表明在这种病理情况下存在阿片调节异常。
