理解性别在阿尔茨海默病中的影响：行动呼吁。
Understanding the impact of sex and gender in Alzheimer's disease: A call to action.
机构信息
Scientific Programs, Society for Women's Health Research (SWHR®), Washington, DC, USA.
Department of Neurological Sciences and the Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
出版信息
Alzheimers Dement. 2018 Sep;14(9):1171-1183. doi: 10.1016/j.jalz.2018.04.008. Epub 2018 Jun 12.
Abstract
INTRODUCTION
Precision medicine methodologies and approaches have advanced our understanding of the clinical presentation, development, progression, and management of Alzheimer's disease (AD) dementia. However, sex and gender have not yet been adequately integrated into many of these approaches.
METHODS
The Society for Women's Health Research Interdisciplinary Network on AD, comprised of an expert panel of scientists and clinicians, reviewed ongoing and published research related to sex and gender differences in AD.
RESULTS
The current review is a result of this Network's efforts and aims to: (1) highlight the current state-of-the-science in the AD field on sex and gender differences; (2) address knowledge gaps in assessing sex and gender differences; and (3) discuss 12 priority areas that merit further research.
DISCUSSION
The exclusion of sex and gender has impeded faster advancement in the detection, treatment, and care of AD across the clinical spectrum. Greater attention to these differences will improve outcomes for both sexes.
摘要
简介
精准医学方法和方法提高了我们对阿尔茨海默病（AD）痴呆的临床表现、发展、进展和管理的理解。然而，许多这些方法还没有充分整合性别差异。
方法
由 AD 领域的科学家和临床医生组成的妇女健康研究跨学科网络协会对与 AD 中的性别差异相关的正在进行和已发表的研究进行了审查。
结果
本综述是该网络努力的结果，旨在：（1）突出 AD 领域中当前关于性别差异的科学现状；（2）解决评估性别差异方面的知识差距；（3）讨论值得进一步研究的 12 个优先领域。
讨论
排除性别差异阻碍了在整个临床范围内更快地发现、治疗和护理 AD。更多地关注这些差异将改善两性的结果。
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