School of Medicine, The University of Texas Health Science Center at Houston, USA.
School of Medicine, The University of Texas Health Science Center at Houston, USA.
Psychiatry Res Neuroimaging. 2018 Aug 30;278:65-68. doi: 10.1016/j.pscychresns.2018.05.006. Epub 2018 Jun 6.
Sodium valproate (VPA) has well-established neuroprotective effects and is recommended as treatment in bipolar disorder patients. The neural effects of VPA in pediatric bipolar disorder (PBD) have yet to be established. This preliminary study explored the effects of VPA on brain structure in PBD. Fourteen PBD patients (10 males; mean = 13.43 ± 3.05 years old) underwent a structural MRI before and after a 6-week VPA treatment period. Bayesian linear mixed modeling explored seven brain region volumes as a function of dichotomous pre/post time. Results showed a decrease in amygdala volume over time. These findings need to be confirmed by large-scale, longitudinal studies.
丙戊酸钠（VPA）具有明确的神经保护作用，被推荐用于双相障碍患者的治疗。VPA 在儿童双相障碍（PBD）中的神经作用尚未确定。本初步研究探讨了 VPA 对 PBD 患者脑结构的影响。14 名 PBD 患者（10 名男性；平均年龄为 13.43 ± 3.05 岁）在 6 周 VPA 治疗前后接受了结构 MRI 检查。贝叶斯线性混合模型探讨了七个脑区体积随二分类时间的函数关系。结果显示杏仁核体积随时间减少。这些发现需要通过大规模的纵向研究来证实。
