CMR Unit and Cardiovascular Research Centre, Royal Brompton Hospital, National Heart & Lung Institute, Imperial College, Sydney Street, SW3 6NP London, United Kingdom.
CMR Unit and Cardiovascular Research Centre, Royal Brompton Hospital, National Heart & Lung Institute, Imperial College, Sydney Street, SW3 6NP London, United Kingdom.
Trends Cardiovasc Med. 2018 Nov;28(8):516-521. doi: 10.1016/j.tcm.2018.05.001. Epub 2018 Jun 12.
The major burden of sudden cardiac death (SCD) in patients with heart disease occurs in those with a left ventricular ejection fraction > 40%. Although the annual risk of SCD may be lower in these patients compared to those with lower LVEF, their lifetime cumulative risk of SCD may be greater due to a better overall prognosis. It is plausible that those with LVEF > 40% who are at highest risk of life-threatening arrhythmia will benefit from implantable cardioverter defibrillators. Features that identify patients with a LVEF > 40% at high risk of SCD are urgently needed. We review existing studies examining SCD markers in this sub-group and discuss gaps in the current evidence base.
患有心脏病的患者中，导致心源性猝死（SCD）的主要负担发生在左心室射血分数（LVEF）>40%的患者中。尽管与 LVEF 较低的患者相比，这些患者每年发生 SCD 的风险可能较低，但由于整体预后较好，他们一生中发生 SCD 的累积风险可能更大。具有 LVEF>40%且发生危及生命的心律失常风险最高的患者可能受益于植入式心脏复律除颤器。因此迫切需要确定 LVEF>40%的患者中 SCD 风险高的患者的特征。我们回顾了现有研究，探讨了该亚组患者中 SCD 标志物的相关问题，并讨论了当前证据基础中的空白。
