Faculty of Science, University of Oradea, Oradea, Romania; Cancer Research Institute and School of Health Sciences, University of South Australia, Adelaide SA, Australia.
GenesisCare, Tennyson Centre, Adelaide SA, Australia; Department of Physics, University of Adelaide, Adelaide SA, Australia.
Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):1165-1182. doi: 10.1016/j.ijrobp.2018.04.055. Epub 2018 May 4.
Improvements in personalized therapy are made possible by the advances in molecular biology that led to developments in molecular imaging, allowing highly specific in vivo imaging of biological processes. Positron emission tomography (PET) is the most specific and sensitive imaging technique for in vivo molecular targets and pathways, offering quantification and evaluation of functional properties of the targeted anatomy.
This work is an integrative research review that summarizes and evaluates the accumulated current status of knowledge of recent advances in PET imaging for cancer diagnosis and treatment, concentrating on novel radiotracers and evaluating their advantages and disadvantages in cancer characterization. Medline search was conducted, limited to English publications from 2007 onward. Identified manuscripts were evaluated for most recent developments in PET imaging of cancer hypoxia, angiogenesis, proliferation, and clonogenic cancer stem cells (CSC).
There is an expansion observed from purely metabolic-based PET imaging toward antibody-based PET to achieve more information on cancer characteristics to identify hypoxia, proangiogenic factors, CSC, and others. Cu-ATSM, for example, can be used both as a hypoxia and a CSC marker.
Progress in the field of functional imaging will possibly lead to more specific tumor targeting and personalized treatment, increasing tumor control and improving quality of life.
分子生物学的进步使得个性化治疗得以改善，这导致了分子成像的发展，从而能够对生物过程进行高度特异性的活体成像。正电子发射断层扫描（PET）是用于活体分子靶标和途径的最特异性和最敏感的成像技术，可定量和评估靶向解剖结构的功能特性。
这是一项综合研究综述，总结和评估了用于癌症诊断和治疗的 PET 成像最新进展的现有知识的累积现状，重点关注新型放射性示踪剂，并评估其在癌症特征描述中的优缺点。进行了 Medline 检索，仅限于 2007 年以后的英文出版物。评估了确定的手稿，以了解癌症缺氧、血管生成、增殖和克隆性癌症干细胞（CSC）的 PET 成像的最新进展。
观察到从纯粹基于代谢的 PET 成像向基于抗体的 PET 成像的扩展，以获得有关癌症特征的更多信息，从而识别缺氧、促血管生成因子、CSC 等。例如，Cu-ATSM 可用作缺氧和 CSC 的标志物。
功能成像领域的进展可能会导致更具特异性的肿瘤靶向和个性化治疗，从而提高肿瘤控制率并提高生活质量。
