Yuen Richard, West Frederick G, Wuest Frank
Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada.
Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Pharmaceutics. 2022 Mar 15;14(3):645. doi: 10.3390/pharmaceutics14030645.
Dual probes that possess positron emission tomography (PET) and fluorescence imaging (FI) capabilities are precision medicine tools that can be used to improve patient care and outcomes. Detecting tumor lesions using PET, an extremely sensitive technique, coupled with fluorescence-guided surgical resection of said tumor lesions can maximize the removal of cancerous tissue. The development of novel molecular probes is important for targeting different biomarkers as every individual case of cancer has different characteristics. This short review will discuss some aspects of dual PET/FI probes and explore the recently reported examples.
具有正电子发射断层扫描（PET）和荧光成像（FI）功能的双探针是精准医疗工具，可用于改善患者护理和治疗效果。使用PET（一种极其灵敏的技术）检测肿瘤病变，再结合对所述肿瘤病变进行荧光引导手术切除，可最大限度地切除癌组织。开发新型分子探针对于靶向不同生物标志物很重要，因为每例癌症都有不同特征。这篇简短综述将讨论双PET/FI探针的一些方面，并探讨最近报道的实例。
