粪便钙卫蛋白检测在幼年特发性关节炎中炎症性肠病的应用。
Fecal Calprotectin to Detect Inflammatory Bowel Disease in Juvenile Idiopathic Arthritis.
机构信息
From the University of Trieste; Institute for Maternal and Child Health - Institute for Research and Health Care (IRCCS) Burlo Garofolo, Trieste, Italy.
G. Ferrara, MD, University of Trieste; S. Pastore, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; L. Sancin, MD, University of Trieste; L. Torelli, MSs, University of Trieste; O. Radillo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; M. Bramuzzo, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; C. Bibalo, MD, University of Trieste; A. Tommasini, MD, Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Ventura, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo; A. Taddio, MD, University of Trieste, and Institute for Maternal and Child Health - IRCCS Burlo Garofolo.
出版信息
J Rheumatol. 2018 Oct;45(10):1418-1421. doi: 10.3899/jrheum.171200. Epub 2018 Jun 15.
OBJECTIVE
This study aimed to test fecal calprotectin (FC) as a screening tool to identify inflammatory bowel disease (IBD) among patients with juvenile idiopathic arthritis (JIA).
METHODS
FC level < 100 g/kg was considered normal. Patients with 2 consecutive FC dosage ≥ 100 g/kg underwent endoscopic evaluation.
RESULTS
There were 113 patients with JIA enrolled. FC was raised in 7 patients out of 113. All patients had IBD. In 3/7 patients, high FC levels were the only sign consistent with IBD.
CONCLUSION
FC is a useful, economical, and noninvasive diagnostic tool to identify JIA patients with underlying IBD.
目的
本研究旨在测试粪便钙卫蛋白（FC）作为一种筛选工具，以识别患有幼年特发性关节炎（JIA）的患者中的炎症性肠病（IBD）。
方法
FC 水平 < 100 g/kg 被认为是正常的。如果连续两次 FC 检测值≥100 g/kg，则进行内镜评估。
结果
共纳入 113 例 JIA 患者。113 例患者中有 7 例 FC 升高。所有患者均患有 IBD。在 7 例患者中的 3 例中，高 FC 水平是唯一与 IBD 一致的迹象。
结论
FC 是一种有用、经济、非侵入性的诊断工具，可用于识别患有潜在 IBD 的 JIA 患者。
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