谁来监管谁：ZNF341 是 STAT3/T17 之歌的另一位参与者。
Who regulates whom: ZNF341 is an additional player in the STAT3/T17 song.
机构信息
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. Email:
出版信息
Sci Immunol. 2018 Jun 15;3(24). doi: 10.1126/sciimmunol.aat9779.
Abstract
Deficiency of ZNF341, a transcription factor featuring 12 Cys2His2 zinc fingers that regulates the expression and autoinduction of STAT3 (signal transducer and activator of transcription 3), results in hyper-immunoglobulin E syndrome and defective T helper 17 cell differentiation in humans.
摘要
ZNF341 缺失，作为一种转录因子具有 12 个 Cys2His2 锌指，调节 STAT3（信号转导和转录激活因子 3）的表达和自诱导，导致人类高免疫球蛋白 E 综合征和辅助性 T 细胞 17 分化缺陷。
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