School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI 48859, USA.
Department of Mathematics, Center for Applied Mathematics & Polymer Fluid Dynamics, Central Michigan University, Mount Pleasant, MI 48859, USA.
J Mech Behav Biomed Mater. 2018 Sep;85:201-208. doi: 10.1016/j.jmbbm.2018.06.002. Epub 2018 Jun 5.
The issue of long-term incompatible interactions associated with the permanent implants can be eliminated by using various biodegradable metal implants. The recent research is focusing on the use of degradable stents to restore most of the hindrances of capillaries, and coronary arteries by supplying instant blood flow with constant mechanical and structural support. However, internal endothelialization and infection due to the corrosion of implanted stents are not easy to diagnose in the long run. In the recent past, magnesium (Mg) has been widely investigated for the cardiovascular stent applications. Here we made an attempt to understand the biodegradation process of Mg alloy stent by studying the degradation of Mg alloy AZ31 (3 wt% Aluminum, 1 wt% Zn) powder at various time-intervals in simulated blood fluid using the Rheological methods. The degradability of the Mg stent in the arteries affects the stress-strain properties of blood plasma and the subsequent flow conditions. Blood and plasma viscosities alter due to the degradation of Mg resulting from the stress-strain experienced in the blood vessels, in which the stent is inserted. Here our objective was to explore the influence of Mg degradation on the blood plasma viscosity by studying the viscoelastic properties. In this work, the effect of dissolution of Mg alloy AZ31 on the rheological properties of Phosphate Buffer Saline (PBS) at various time intervals have been investigated. The viscosity of the PBS-AZ31 solution increased with the dissolution of both slurries and percolated clear solution. The only exception was day-7 of the percolated clear solution, where viscosity was decreased showing a reduction in viscosity at initial stages of dissolution. The frequency sweep showed the tendency of the PBS-AZ31 gelation up to 100 rad/s frequency.
长期不相容的相互作用问题与永久性植入物有关，可以通过使用各种可生物降解的金属植入物来消除。最近的研究集中在使用可降解支架来恢复毛细血管和冠状动脉的大部分阻塞，通过提供即时血流和持续的机械和结构支撑来恢复。然而，由于植入支架的腐蚀，内部内皮化和感染在长期内不容易诊断。在最近的过去，镁（Mg）已被广泛用于心血管支架应用。在这里，我们试图通过在模拟血液中用流变学方法研究 AZ31 镁合金（3wt%铝，1wt%锌）粉末在不同时间间隔的降解来了解镁合金支架的降解过程。镁支架在动脉中的可降解性会影响血浆的应力-应变特性和随后的流动条件。由于血管中插入支架时的应力-应变，Mg 的降解会导致血液和血浆粘度发生变化。在这里，我们的目的是通过研究粘弹性来探索 Mg 降解对血浆粘度的影响。在这项工作中，研究了在不同时间间隔下 AZ31 镁合金在磷酸盐缓冲盐水（PBS）中的溶解对流变性能的影响。PBS-AZ31 溶液的粘度随着悬浮液和渗透清液的溶解而增加。唯一的例外是渗透清液的第 7 天，其中粘度降低，表明在溶解的初始阶段粘度降低。频率扫描显示 PBS-AZ31 凝胶化的趋势高达 100rad/s 频率。
