Wu Weiwei, Yu Xiaoming, Zhao Yan, Jiang Xiran, Yang Huazhe
School of Fundamental Sciences and School of Pharmacy, China Medical University, Shenyang 110122, PR China.
Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, PR China.
ACS Omega. 2019 Sep 6;4(12):15139-15148. doi: 10.1021/acsomega.9b02041. eCollection 2019 Sep 17.
Biodegradable Mg alloys have good bioactivity and suitable mechanical properties, which is desirable for application in the clinical fields. However, the biocompatibility of Mg alloys during the degradation process has always been a concern. In this paper, the corrosion behavior of AZ91 alloys in a simulated cell culture environment was studied, especially the insoluble corrosion product during the degradation was characterized, and the biocompatibility of the insoluble corrosion products was evaluated. The results of immersion test showed that the corrosion rate of the AZ91 alloy was low under the condition of high CO and humidity, especially in phosphate-buffered saline. Moreover, the insoluble corrosion product was MgCO·3HO, which showed a needle-like, circular aggregated, and square-radial feature. Meanwhile, MgCO·3HO showed poor cell biocompatibility by increasing the pH and Mg content of the culture solution, which may affect the biocompatibility of Mg alloys.
可生物降解镁合金具有良好的生物活性和合适的力学性能，这使其在临床领域的应用备受期待。然而，镁合金在降解过程中的生物相容性一直是人们关注的问题。本文研究了AZ91合金在模拟细胞培养环境中的腐蚀行为，特别对降解过程中不溶性腐蚀产物进行了表征，并评估了不溶性腐蚀产物的生物相容性。浸泡试验结果表明，在高CO₂和湿度条件下，尤其是在磷酸盐缓冲盐水中，AZ91合金的腐蚀速率较低。此外，不溶性腐蚀产物为MgCO₃·3H₂O，呈现针状、圆形聚集和方形径向特征。同时，MgCO₃·3H₂O通过增加培养液的pH值和镁含量，表现出较差的细胞生物相容性，这可能会影响镁合金的生物相容性。
