Ely P Haines
VA North California Health Care System, Mather, CA; University of California Davis School of Medicine, Sacramento, CA; Department of Dermatology, Sacramento VA Medical Center, Mather, CA.
Clin Dermatol. 2018 May-Jun;36(3):376-389. doi: 10.1016/j.clindermatol.2018.03.011. Epub 2018 Mar 28.
The gut is the largest lymphoid organ in the body. The human microbiome is composed of trillions of bacteria. The DNA of these bacteria dwarfs the human genome. Diet and ethanol can cause rapid shifts in the number and types of bacteria in the gut. The psoriatic microbiome is similar to that seen in alcoholics; there is a decrease in bacterial diversity and overgrowth of bacteria in the small bowel. Psoriatics often have liver disease and deficiencies in bile acids. Psoriasis is a disease characterized by a leaky gut. All of the comorbidities of this disease are due to systemic endotoxemia. Bacterial peptidoglycans absorbed from the gut have direct toxic effects on the liver and skin. Their absorption, as well as endotoxin absorption, must be eliminated to treat psoriasis successfully. Endotoxin absorption is markedly increased by ethanol and peppers. Bioflavonoids, such as quercetin and citrus bioflavonoids, prevent this absorption. Bile acids, given orally, break up endotoxin in the intestinal lumen. Pathogens, including Helicobacter pylori and Streptococcus pyogenes, must be eliminated with antimicrobial therapy for any treatment to work. A complete protocol for curing psoriasis is provided.
肠道是人体最大的淋巴器官。人类微生物群由数万亿细菌组成。这些细菌的DNA使人类基因组相形见绌。饮食和乙醇会导致肠道内细菌数量和种类迅速变化。银屑病患者的微生物群与酗酒者相似；细菌多样性降低，小肠内细菌过度生长。银屑病患者常患有肝脏疾病且胆汁酸缺乏。银屑病是一种以肠道渗漏为特征的疾病。该疾病的所有合并症都归因于全身性内毒素血症。从肠道吸收的细菌肽聚糖对肝脏和皮肤有直接毒性作用。为成功治疗银屑病，必须消除它们的吸收以及内毒素的吸收。乙醇和辣椒会显著增加内毒素的吸收。生物类黄酮，如槲皮素和柑橘生物类黄酮，可防止这种吸收。口服胆汁酸可分解肠腔内的内毒素。对于任何有效的治疗，包括幽门螺杆菌和化脓性链球菌在内的病原体都必须通过抗菌疗法消除。本文提供了一个治愈银屑病的完整方案。
