地塞米松对大鼠垂体细胞单层培养中垂体激素释放的影响。

Effect of dexamethasone on the release of pituitary hormones in monolayer cultures of rat pituitary cells.

作者信息

Nakagawa K, Obara T, Matsubara M, Kubo M

出版信息

Endocrinol Jpn. 1985 Feb;32(1):61-4. doi: 10.1507/endocrj1954.32.61.

DOI:10.1507/endocrj1954.32.61

Abstract

The effect of dexamethasone on the release of ACTH, GH, PRL, LH and TSH was studied in monolayer cultures of rat pituitary cells in 4-hour incubation. With or without the addition of rat hypothalamic extract, the release of GH was significantly inhibited by dexamethasone at concentrations higher than 10(-9) M, although less remarkably than that of ACTH. Intracellular ACTH and GH were unchanged. PRL, LH and TSH were not affected. These results indicate that dexamethasone, when exerted for 4 hours, suppressed the release of GH as well as ACTH, at least in part, at the pituitary level.

摘要

在大鼠垂体细胞单层培养物中进行4小时孵育，研究了地塞米松对促肾上腺皮质激素（ACTH）、生长激素（GH）、催乳素（PRL）、促黄体生成素（LH）和促甲状腺激素（TSH）释放的影响。无论是否添加大鼠下丘脑提取物，浓度高于10（-9）M的地塞米松均可显著抑制GH的释放，尽管其抑制程度不如对ACTH的抑制显著。细胞内ACTH和GH未发生变化。PRL、LH和TSH未受影响。这些结果表明，地塞米松作用4小时时，至少在垂体水平上部分抑制了GH以及ACTH的释放。