Lorenzoni Paulo José, Ducci Renata Dal-Prá, Dalledone Giuliano Ohde, Kay Claudia Suemi Kamoi, de Almeida Sérgio Monteiro, Werneck Lineu Cesar, Scola Rosana Hermínia
Service of Neuromuscular Disorders, Division of Neurology, Department of Internal Medicine, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), 80060-900, Curitiba, Brazil.
Service of Neuromuscular Disorders, Division of Neurology, Department of Internal Medicine, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), 80060-900, Curitiba, Brazil.
Clin Neurol Neurosurg. 2018 Aug;171:139-142. doi: 10.1016/j.clineuro.2018.06.006. Epub 2018 Jun 10.
HIV-associated motor neuron disease (MND), or amyotrophic lateral sclerosis (ALS)-like syndrome associated with HIV infection, is a rare manifestation of HIV infection. HIV-associated MND has only been identified in few cases to date. We analysed two Brazilian patients with HIV infection who developed MND. The diagnosis of HIV infection was concomitant with diagnosis of MND in one patient and it occurred eight years before the MND symptoms in another patient. The manifestation of MND in our patients with HIV infection was similar to classic ALS. The antiretroviral therapy improves their HIV infection. However, slow progression of MND occurred in the two patients despite their antiretroviral therapy or HIV viral load (undetectable). We revised the international literature (PubMed database) of the patients reported with MND and HIV infection.
人类免疫缺陷病毒（HIV）相关运动神经元病（MND），即与HIV感染相关的肌萎缩侧索硬化症（ALS）样综合征，是HIV感染的一种罕见表现。迄今为止，仅在少数病例中发现了HIV相关MND。我们分析了两名患MND的巴西HIV感染患者。其中一名患者HIV感染诊断与MND诊断同时发生，另一名患者的HIV感染发生在MND症状出现的八年前。我们的HIV感染患者中MND的表现与经典ALS相似。抗逆转录病毒疗法改善了他们的HIV感染情况。然而，尽管进行了抗逆转录病毒治疗且HIV病毒载量检测不到（低于检测下限），这两名患者的MND仍进展缓慢。我们查阅了报告有MND和HIV感染患者的国际文献（PubMed数据库）。
