Sabbadini Pedro V, Orsini Marco A, Amorelli Figueira João Carlos, Ashmawi Omar H, Amorelli Fernandes Amanda, Costa Joao V, De Mello Tavares Thiago, De Freitas Marcos, Oliveira Acary S, McBenedict Billy
Neurology, Fluminense Federal University, Niterói, BRA.
Neurology, Federal University of Rio de Janeiro, Rio de Janeiro, BRA.
Cureus. 2025 Aug 7;17(8):e89530. doi: 10.7759/cureus.89530. eCollection 2025 Aug.
Motor neuron disease and parkinsonism syndromes associated with chronic HIV infection are extremely rare, with only a few cases reported in major medical databases. We report a case from Brazil involving a patient with a chronic, well-controlled HIV infection for approximately 15 years, demonstrating a good response to highly active antiretroviral therapy. Despite the absence of viral replication, the patient developed atypical clinical and topographical features consistent with both pyramidal and extrapyramidal syndromes. This raises the question of whether such findings could be linked to chronic HIV infection, occurring simultaneously even in the absence of active viral replication, particularly given that other potential diagnoses were excluded.
与慢性HIV感染相关的运动神经元病和帕金森综合征极为罕见，主要医学数据库中仅报告了少数病例。我们报告一例来自巴西的病例，患者慢性HIV感染病情得到良好控制约15年，对高效抗逆转录病毒疗法反应良好。尽管没有病毒复制，但该患者出现了与锥体束和锥体外系综合征一致的非典型临床和定位特征。这就提出了一个问题，即这些发现是否可能与慢性HIV感染有关，即使在没有病毒活跃复制的情况下也会同时出现，特别是考虑到已排除其他潜在诊断。
