Division of Pediatric Urology, Children's Hospital of Philadelphia, Philadelphia, USA.
Division of Pediatric Urology, Children's Hospital of Philadelphia, Philadelphia, USA.
J Pediatr Urol. 2018 Dec;14(6):540.e1-540.e6. doi: 10.1016/j.jpurol.2018.04.023. Epub 2018 Jun 1.
Although shown to be safe in infancy, robotic-assisted laparoscopic pyeloplasty (RALP) for ureteropelvic junction obstruction (UPJO) is most commonly performed in older children and adolescents.
This study examined a contemporary RALP experience at a single tertiary pediatric center and compared outcomes in infants aged ≤1 year with an older cohort.
All RALP procedures were entered into an Institutional Review Board-approved data registry from 2012 to 2016. Patients were retrospectively grouped according to age. The primary outcome was success rate. Secondary outcomes included complications and length of hospital stay. Failure was defined as the need for secondary surgical intervention for UPJO or worsening urinary tract dilation on imaging. Statistical analysis was performed using SPSS version 20. Mann-Whitney U testing was used for comparison.
A total of 138 patients underwent RALP during 2012-2016, with a median age of 6 years (IQR 1, 13.25) and a male:female ratio of approximately 2:1. Of these, 34 (24.6%) were aged ≤1 year. Of all patients, 60 (43.5%) presented with a history of prenatal hydronephrosis, and 32% had a crossing vessel causing obstruction. An indwelling stent was placed in antegrade fashion in 71% of cases, and 18% had a percutaneously placed externalized stent. There were six (4%) failures requiring reoperation. Multivariate and comparative analysis demonstrated that the infant cohort utilized less morphine equivalents and more often had a percutaneous stent placed compared to the older cohort. Of the complications that occurred, 60% were minor (Clavien grades 1 and 2) and 40% were Clavien grade 3 in the infant cohort, and 70.1% and 29.9% in the older cohort, respectively. No studied criteria predicted failure in either cohort.
This study presented one of the largest contemporary series of consecutive pediatric RALPs, and showed an overall success rate of 96%. There were no significant differences in length of hospital stay, and complications or failure rates in infants compared to older children. This study substantiated the ongoing trend towards the adaptation of robotic-assisted surgery for the entire pediatric patient population.
虽然机器人辅助腹腔镜肾盂成形术(RALP)已被证明在婴儿期是安全的,但它最常用于年龄较大的儿童和青少年的治疗。
本研究在一家儿科三级中心检查了最新的 RALP 经验,并比较了≤1 岁婴儿组和较大年龄组的治疗结果。
所有 RALP 手术均纳入机构审查委员会批准的数据登记处,时间为 2012 年至 2016 年。根据年龄将患者分组。主要结果是成功率。次要结果包括并发症和住院时间。失败定义为需要二次手术干预肾盂输尿管连接部梗阻或影像学上尿路扩张恶化。使用 SPSS 版本 20 进行统计分析。使用 Mann-Whitney U 检验进行比较。
2012-2016 年期间,共有 138 例患者接受了 RALP,中位年龄为 6 岁(IQR 1, 13.25),男女比例约为 2:1。其中 34 例(24.6%)年龄≤1 岁。所有患者中,60 例(43.5%)有产前肾积水病史,32%有交叉血管引起梗阻。71%的病例采用逆行留置支架,18%采用经皮外置支架。有 6 例(4%)失败需要再次手术。多变量和比较分析表明,婴儿组比大龄组使用吗啡等效物更少,更常使用经皮支架。发生的并发症中,婴儿组 60%为轻微并发症(Clavien 1 级和 2 级),40%为 Clavien 3 级,大龄组分别为 70.1%和 29.9%。在两个队列中,均无研究标准预测失败。
本研究提供了最新的大型连续儿科 RALP 系列之一,总成功率为 96%。与大龄儿童相比,婴儿组的住院时间、并发症或失败率无显著差异。本研究证实了机器人辅助手术在整个儿科患者群体中的应用趋势。