Rotman Research Institute, Baycrest Centre, Toronto, Canada; Department of Psychology, Trent University, Peterborough, Canada; Departments of Psychology and Psychiatry, University of Toronto, Toronto, Canada.
School of Psychology, The University of Sydney, Sydney, Australia.
Cancer Treat Rev. 2018 Sep;69:72-83. doi: 10.1016/j.ctrv.2018.05.017. Epub 2018 Jun 1.
Cancer survivors who undergo chemotherapy for non-CNS tumours often report substantial cognitive disturbances that adversely affect quality of life, during and after treatment. The neurotoxic effects of anti-cancer drugs have been confirmed in clinical and pre-clinical research. Work with animals has also identified a range of factors and underlying mechanisms that contribute to chemotherapy-induced cognitive impairment. However, there is a continuing need to develop standard cognitive testing procedures for validation and comparison purposes, broaden the search for biological and neurochemical mechanisms, and develop improved animal models for investigating the combined effects of treatment, the disease, and other potential factors (e.g., age, stress). In this paper, a working group, formed under the auspices of the International Cognition and Cancer Task Force, reviews the state of pre-clinical research, formulates strategic priorities, and provides recommendations to guide animal research that meaningfully informs clinical investigations.
接受非中枢神经系统肿瘤化疗的癌症幸存者在治疗期间和治疗后常报告大量认知障碍，这些障碍会对生活质量产生不利影响。临床和临床前研究证实了抗癌药物的神经毒性作用。动物研究还确定了一系列导致化疗引起的认知障碍的因素和潜在机制。然而，仍需要开发标准的认知测试程序以进行验证和比较，扩大对生物学和神经化学机制的研究，并开发改进的动物模型以研究治疗、疾病和其他潜在因素（如年龄、压力）的综合影响。在本文中，一个在国际认知与癌症工作组的支持下成立的工作组审查了临床前研究的现状，制定了战略重点，并提出了建议，以指导具有重要意义的动物研究，为临床研究提供信息。
