Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France; INSERM, U1222, Paris, France; Université Pierre et Marie Curie, Paris, France.
Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France; INSERM, U1222, Paris, France; Université Pierre et Marie Curie, Paris, France; Neovacs SA, Paris, France.
Pharmacol Ther. 2018 Nov;191:50-64. doi: 10.1016/j.pharmthera.2018.05.015. Epub 2018 Jun 27.
IgE is the antibody isotype found at the lowest concentration in the circulation. However IgE can undeniably play an important role in mediating allergic reactions; best exemplified by the clinical benefits of anti-IgE monoclonal antibody (omalizumab) therapy for some allergic diseases. This review will describe our current understanding of the interactions between IgE and its main receptors FcεRI and CD23 (FcεRII). We will review the known and potential functions of IgE in health and disease: in particular, its detrimental roles in allergic diseases and chronic spontaneous urticaria, and its protective functions in host defense against parasites and venoms. Finally, we will present an overview of the drugs that are in clinical development or have therapeutic potential for IgE-mediated allergic diseases.
IgE 是在循环中浓度最低的抗体同种型。然而，IgE 无疑可以在介导过敏反应中发挥重要作用；抗 IgE 单克隆抗体（奥马珠单抗）治疗某些过敏性疾病的临床获益就是最好的例证。这篇综述将描述我们目前对 IgE 与其主要受体 FcεRI 和 CD23（FcεRII）之间相互作用的理解。我们将回顾 IgE 在健康和疾病中的已知和潜在功能：特别是其在过敏性疾病和慢性自发性荨麻疹中的有害作用，以及其在宿主防御寄生虫和毒液中的保护作用。最后，我们将概述临床开发或具有 IgE 介导的过敏性疾病治疗潜力的药物。
