人IgE不与人FcRn结合。
Human IgE does not bind to human FcRn.
作者信息
Brinkhaus Maximilian, van der Kooi Elvera J, Bentlage Arthur E H, Ooijevaar-de Heer Pleuni, Derksen Ninotska I L, Rispens Theo, Vidarsson Gestur
机构信息
Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands.
Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
出版信息
Sci Rep. 2022 Jan 7;12(1):62. doi: 10.1038/s41598-021-03852-1.
The neonatal Fc receptor (FcRn) is known to mediate placental transfer of IgG from mother to unborn. IgE is widely known for triggering immune responses to environmental antigens. Recent evidence suggests FcRn-mediated transplacental passage of IgE during pregnancy. However, direct interaction of FcRn and IgE was not investigated. Here, we compared binding of human IgE and IgG variants to recombinant soluble human FcRn with β2-microglobulin (sFcRn) in surface plasmon resonance (SPR) at pH 7.4 and pH 6.0. No interaction was found between human IgE and human sFcRn. These results imply that FcRn can only transport IgE indirectly, and thereby possibly transfer allergenic sensitivity from mother to fetus.
已知新生儿Fc受体（FcRn）介导IgG从母亲到未出生胎儿的胎盘转运。IgE因引发对环境抗原的免疫反应而广为人知。最近的证据表明，孕期FcRn介导IgE的胎盘转运。然而，尚未研究FcRn与IgE的直接相互作用。在此，我们在pH 7.4和pH 6.0条件下，通过表面等离子体共振（SPR）比较了人IgE和IgG变体与重组可溶性人FcRn及β2-微球蛋白（sFcRn）的结合情况。未发现人IgE与人sFcRn之间存在相互作用。这些结果表明，FcRn只能间接转运IgE，从而可能将过敏敏感性从母亲传递给胎儿。
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