Department of Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Department of Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Pharmacol Rep. 2018 Aug;70(4):661-667. doi: 10.1016/j.pharep.2018.02.003. Epub 2018 Feb 3.
Although adenosine plays a key role in multiple motor, affective, and cognitive processes, it has received less attention in the neuroscience field compared to other neurotransmitters (e.g., dopamine). In this review, we highlight the role of adenosine in behavior as well as its interaction with other neurotransmitters, such as dopamine. We also discuss brain disorders impacted by alterations to adenosine, and how targeting adenosine can ameliorate Parkinson's disease motor symptoms. We also discuss the role of caffeine (as an adenosine antagonist) on cognition as well as a neuroprotective agent against Parkinson's disease (PD).
尽管腺苷在多种运动、情感和认知过程中发挥着关键作用，但与其他神经递质（如多巴胺）相比，它在神经科学领域受到的关注较少。在这篇综述中，我们强调了腺苷在行为中的作用及其与其他神经递质（如多巴胺）的相互作用。我们还讨论了受腺苷改变影响的脑部疾病，以及如何通过靶向腺苷来改善帕金森病的运动症状。我们还讨论了咖啡因（作为腺苷拮抗剂）对认知的作用以及其作为帕金森病（PD）神经保护剂的作用。
