Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Department of Dermatology, Elisabeth-TweeSteden Hospital, Tilburg, the Netherlands.
Dermatology. 2018;234(1-2):60-65. doi: 10.1159/000489118. Epub 2018 Jun 15.
The Actinic Keratosis Quality of Life Questionnaire (AKQoL) is a disease-specific instrument to measure the impact of actinic keratosis (AK) on patients' lives.
To validate and test the psychometric properties of the AKQoL translated into the Dutch language (AKQoL-NL).
All new patients ≥50 years of age with untreated AK in a university medical center and a general hospital between August 2014 and August 2015 were eligible. The AKQoL was obtained and repeated after 2 weeks. The feasibility was tested by missing responses and response distribution. The internal consistency reliability of each domain was investigated with the Cronbach alpha, and test-retest reliability and validity with the Spearman correlation coefficient. AKQoL scores were compared to the Skindex-17 for convergent validity and to the Groningen Frailty Indicator scores for divergent validity.
A total of 153 of 190 eligible patients consented to participate. Feasibility analysis showed that none of the items missed ≥10% of responses but 5 of the 9 items showed floor effect. The AKQoL subscales showed a moderate internal consistency (Cronbach α = 0.235-0.468) and an excellent test-retest reliability (interclass correlation coefficient = 0.997-1). The AKQoL correlated poorly with the symptom component and moderately with the psychosocial component of the Skindex-17 (ρ = -0.015 to 0.346 and 0.324 to 0.501, respectively), which is less than expected. The AKQoL scored poorly in both of the Groningen Frailty Indicator (GFI) components (ρ = -0.97 to 0.12 and 0.185 to 0.276, respectively), as expected.
The AKQoL-NL is a feasible, moderately valid, and moderately reliable health-related quality of life questionnaire.
光化性角化病生活质量问卷（AKQoL）是一种专门用于测量光化性角化病（AK）对患者生活影响的疾病特异性工具。
验证并测试翻译成荷兰语的 AKQoL（AKQoL-NL）的心理测量特性。
2014 年 8 月至 2015 年 8 月期间，在一所大学医学中心和一家综合医院中，所有年龄≥50 岁且未经治疗的 AK 的新患者均符合入组条件。获得 AKQoL 并在 2 周后重复。通过缺失反应和反应分布来测试可行性。使用 Cronbach α 检验各领域的内部一致性可靠性，使用 Spearman 相关系数检验重测信度和有效性。将 AKQoL 评分与 Skindex-17 进行收敛有效性比较，并与 Groningen 脆弱性指标评分进行发散有效性比较。
共有 190 名符合条件的患者中有 153 名同意参加。可行性分析表明，没有一个项目的缺失率超过 10%，但 9 个项目中有 5 个出现了地板效应。AKQoL 分量表的内部一致性中等（Cronbach α=0.235-0.468），重测信度极好（组内相关系数=0.997-1）。AKQoL 与 Skindex-17 的症状成分相关性较差，与心理社会成分相关性中等（ρ=-0.015 至 0.346 和 0.324 至 0.501），低于预期。AKQoL 在 Groningen 脆弱性指标的两个组成部分中的得分都较差（ρ=-0.97 至 0.12 和 0.185 至 0.276），这与预期相符。
AKQoL-NL 是一种可行、中等有效和中等可靠的健康相关生活质量问卷。
