荷兰语版光化性角化病生活质量问卷（AKQoL）的有效性和可靠性。
Validity and Reliability of the Dutch Adaptation of the Actinic Keratosis Quality of Life Questionnaire (AKQoL).
机构信息
Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Department of Dermatology, Elisabeth-TweeSteden Hospital, Tilburg, the Netherlands.
出版信息
Dermatology. 2018;234(1-2):60-65. doi: 10.1159/000489118. Epub 2018 Jun 15.
BACKGROUND
The Actinic Keratosis Quality of Life Questionnaire (AKQoL) is a disease-specific instrument to measure the impact of actinic keratosis (AK) on patients' lives.
OBJECTIVE
To validate and test the psychometric properties of the AKQoL translated into the Dutch language (AKQoL-NL).
METHODS
All new patients ≥50 years of age with untreated AK in a university medical center and a general hospital between August 2014 and August 2015 were eligible. The AKQoL was obtained and repeated after 2 weeks. The feasibility was tested by missing responses and response distribution. The internal consistency reliability of each domain was investigated with the Cronbach alpha, and test-retest reliability and validity with the Spearman correlation coefficient. AKQoL scores were compared to the Skindex-17 for convergent validity and to the Groningen Frailty Indicator scores for divergent validity.
RESULTS
A total of 153 of 190 eligible patients consented to participate. Feasibility analysis showed that none of the items missed ≥10% of responses but 5 of the 9 items showed floor effect. The AKQoL subscales showed a moderate internal consistency (Cronbach α = 0.235-0.468) and an excellent test-retest reliability (interclass correlation coefficient = 0.997-1). The AKQoL correlated poorly with the symptom component and moderately with the psychosocial component of the Skindex-17 (ρ = -0.015 to 0.346 and 0.324 to 0.501, respectively), which is less than expected. The AKQoL scored poorly in both of the Groningen Frailty Indicator (GFI) components (ρ = -0.97 to 0.12 and 0.185 to 0.276, respectively), as expected.
CONCLUSION
The AKQoL-NL is a feasible, moderately valid, and moderately reliable health-related quality of life questionnaire.
背景
光化性角化病生活质量问卷（AKQoL）是一种专门用于测量光化性角化病（AK）对患者生活影响的疾病特异性工具。
目的
验证并测试翻译成荷兰语的 AKQoL（AKQoL-NL）的心理测量特性。
方法
2014 年 8 月至 2015 年 8 月期间，在一所大学医学中心和一家综合医院中，所有年龄≥50 岁且未经治疗的 AK 的新患者均符合入组条件。获得 AKQoL 并在 2 周后重复。通过缺失反应和反应分布来测试可行性。使用 Cronbach α 检验各领域的内部一致性可靠性，使用 Spearman 相关系数检验重测信度和有效性。将 AKQoL 评分与 Skindex-17 进行收敛有效性比较，并与 Groningen 脆弱性指标评分进行发散有效性比较。
结果
共有 190 名符合条件的患者中有 153 名同意参加。可行性分析表明，没有一个项目的缺失率超过 10%，但 9 个项目中有 5 个出现了地板效应。AKQoL 分量表的内部一致性中等（Cronbach α=0.235-0.468），重测信度极好（组内相关系数=0.997-1）。AKQoL 与 Skindex-17 的症状成分相关性较差，与心理社会成分相关性中等（ρ=-0.015 至 0.346 和 0.324 至 0.501），低于预期。AKQoL 在 Groningen 脆弱性指标的两个组成部分中的得分都较差（ρ=-0.97 至 0.12 和 0.185 至 0.276），这与预期相符。
结论
AKQoL-NL 是一种可行、中等有效和中等可靠的健康相关生活质量问卷。
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