Hashimoto Mamoru, Matsumura Naoki, Ohzeki Takayuki, Hongo Sachiko, Sugimoto Koichi, Shimizu Nobutaka, Mori Yasunori, Minami Takafumi, Nozawa Masahiro, Nose Kazuhiro, Tahara Hideo, Yoshimura Kazuhiro, Uemura Hirotsugu
Department of Urology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.
Department of Urology, Mimihara General Hospital, Sakai, Japan.
Urol Int. 2018;101(1):74-79. doi: 10.1159/000489400. Epub 2018 Jun 15.
We investigated whether the change in the neutrophil lymphocyte ratio (NLR) from the first to the last repeat prostate biopsy (ΔNLR) could be the diagnostic tool or not for prostate cancer (PCa) detection.
We retrospectively evaluated medical records of men who had undergone repeat prostate biopsy. The investigated parameters were white blood cell, neutrophil, lymphocyte counts, NLR at the last prostate biopsy, ΔNLR, prostate-specific antigen (PSA), PSA density (PSAD), and PSA velocity. Exclusion criteria were the presence of cancers other than prostate origin, medication, and diseases which induce the change of NLR.
A total of 301 men who had undergone repeat prostate biopsy were selected for this study. After applying exclusion criteria, 223 patients were included. Of these patients, 94 were diagnosed with PCa (Group I) and 129 with no malignancy (Group II). Only a single patient had metastasis. On evaluating the area under the receiver operating characteristic curve of all study parameters, ΔNLR was the most accurate marker, followed by PSAD and then NLR measured at the last biopsy.
ΔNLR was the most accurate marker to improve the total predictive value in repeat prostate biopsy for diagnosing PCa.
我们研究了从首次重复前列腺活检到最后一次重复前列腺活检中性粒细胞淋巴细胞比值（NLR）的变化（ΔNLR）是否可作为前列腺癌（PCa）检测的诊断工具。
我们回顾性评估了接受重复前列腺活检男性的病历。研究参数包括白细胞、中性粒细胞、淋巴细胞计数、最后一次前列腺活检时的NLR、ΔNLR、前列腺特异性抗原（PSA）、PSA密度（PSAD）和PSA速率。排除标准为存在前列腺以外来源的癌症、用药情况以及导致NLR变化的疾病。
本研究共纳入301例接受重复前列腺活检的男性。应用排除标准后，纳入223例患者。其中，94例被诊断为PCa（I组），129例无恶性肿瘤（II组）。仅1例患者发生转移。在评估所有研究参数的受试者工作特征曲线下面积时，ΔNLR是最准确的标志物，其次是PSAD，然后是最后一次活检时测得的NLR。
在重复前列腺活检诊断PCa时，ΔNLR是提高总预测价值的最准确标志物。
