Naito Hirohito, Sugimoto Mikio, Taketa Shigeo, Kakehi Yoshiyuki
The Department of Urology, Mizushima Kyodo Hospital.
The Department of Urology, Kagawa University Faculty of Medicine.
Hinyokika Kiyo. 2017 Feb;63(2):63-67. doi: 10.14989/ActaUrolJap_63_2_63.
Neutrophil-to-lymphocyte ratio (NLR), a simple marker of systemic inflammatory response, has clinical and prognostic value in patients with cancer. We evaluated the role of NLR prior to biopsy in patients suspected of having cancer prostate cancer. In this retrospective study, we reviewed the records of 204 patients who underwent prostate biopsy in Mizushima Kyodo Hospital between August 2002 and June 2015 and collected the following data : age, C-reactive protein (CRP), prostate volume (PV), clinical cancer staging, prostate-specific antigen (PSA) prior to biopsy , Gleason score (GS), NLR. NLR was calculated by prebiopsy neutrophil and lymphocyte counts. We divided the 83 of 204 patients found to have prostate cancer (PCa) into two or three groups by the results of biopsy, PSA, clinical cancer staging, GS, and D'Amico risk classification. Mann-Whitney U-test and Kruskal-Wallis H-test were used to compare NLR in each group. Significant differences were recognized in NLR between the groups : PSA≧10 ng/ml VS ＜ 10 ng/ml in all patients and in patients with cancer, cT2b≧ VS cT2c≦, GS 6 VS GS 7 VS GS 8≦ in patients with cancer and low risk VS intermediate risk VS high risk in patients with cancer without metastasis. Also we investigated the correlated factor with NLR in patients with cancer without metastasis. On multiple regression analysis including age, CRP, PV, PSA, clinical tumor stage and GS, PSA and GS had a significant association with NLR.
中性粒细胞与淋巴细胞比值（NLR）是全身炎症反应的一个简单指标，在癌症患者中具有临床和预后价值。我们评估了NLR在疑似前列腺癌患者活检前的作用。在这项回顾性研究中，我们查阅了2002年8月至2015年6月期间在水岛协同医院接受前列腺活检的204例患者的记录，并收集了以下数据：年龄、C反应蛋白（CRP）、前列腺体积（PV）、临床癌症分期、活检前前列腺特异性抗原（PSA）、 Gleason评分（GS）、NLR。NLR通过活检前中性粒细胞和淋巴细胞计数计算得出。我们根据活检结果、PSA、临床癌症分期、GS和达米科风险分类，将204例被诊断为前列腺癌（PCa）的患者中的83例分为两组或三组。采用Mann-Whitney U检验和Kruskal-Wallis H检验比较各组的NLR。各组之间的NLR存在显著差异：所有患者以及癌症患者中PSA≧10 ng/ml与＜10 ng/ml相比，癌症患者中cT2b≧与cT2c≦相比，癌症患者中GS 6与GS 7与GS 8≦相比，无转移癌症患者中低风险与中度风险与高风险相比。我们还研究了无转移癌症患者中与NLR相关的因素。在包括年龄、CRP、PV、PSA、临床肿瘤分期和GS的多元回归分析中，PSA和GS与NLR有显著关联。
