对δ1-四氢大麻酚低温效应产生耐受的小鼠大脑中δ1-四氢大麻酚及其代谢物的水平
Brain levels of delta1-tetrahydrocannabinol and its metabolites in mice tolerant to the hypothermic effect of delta1-tetrahydrocannabinol.
作者信息
Lawrence D K, Pertwee R G
出版信息
Br J Pharmacol. 1973 Oct;49(2):373-5. doi: 10.1111/j.1476-5381.1973.tb08388.x.
Abstract
Repeated voluntary consumption of cannabis in milk (approximately 8 mg per day for 15 days) produced in mice tolerance to the hypothermic effect of tritiated Delta(1)-tetrahydrocannabinol ([(3)H]-Delta(1)-THC; 2 mg/kg i.v.) but not to the effect of [(3)H]-Delta(1)-THC on immobility index. The development of tolerance was not accompanied by any detectable change in levels of radioactivity in the brain assigned to Delta(1)-THC or its metabolites. It was concluded that changes in metabolism or distribution of Delta(1)-THC are not responsible for tolerance at least to the hypothermic effect of Delta(1)-THC in mice.
摘要
让小鼠反复自愿摄入含大麻的牛奶（每天约8毫克，持续15天），可使其对氚标记的Δⁱ-四氢大麻酚（[³H]-Δⁱ-THC；静脉注射2毫克/千克）的低温效应产生耐受性，但对[³H]-Δⁱ-THC对不动指数的影响不产生耐受性。耐受性的形成并未伴随大脑中分配给Δⁱ-THC或其代谢物的放射性水平出现任何可检测到的变化。得出的结论是，至少对小鼠中Δⁱ-THC的低温效应而言，Δⁱ-THC代谢或分布的变化并非耐受性产生的原因。
相似文献
1
Brain levels of delta1-tetrahydrocannabinol and its metabolites in mice tolerant to the hypothermic effect of delta1-tetrahydrocannabinol.对δ1-四氢大麻酚低温效应产生耐受的小鼠大脑中δ1-四氢大麻酚及其代谢物的水平
Br J Pharmacol. 1973 Oct;49(2):373-5. doi: 10.1111/j.1476-5381.1973.tb08388.x.
2
Tolerance to the effect of delta1-tetrahydrocannabinol on corticosterone levels in mouse plasma produced by repeated administration of cannabis extract or delta1-tetrahydrocannabinol.通过重复给予大麻提取物或δ1-四氢大麻酚产生对δ1-四氢大麻酚对小鼠血浆皮质酮水平影响的耐受性。
Br J Pharmacol. 1974 Jul;51(3):391-7. doi: 10.1111/j.1476-5381.1974.tb10674.x.
3
Cross-tolerance to the hypothermic effect of delta 8-tetrahydrocannabinol 11-hydroxy-delta 8-tetrahydrocannabinol and chlorpromazine in the mouse.小鼠对δ8-四氢大麻酚、11-羟基-δ8-四氢大麻酚和氯丙嗪低温效应的交叉耐受性。
Eur J Pharmacol. 1985 May 8;111(2):159-66. doi: 10.1016/0014-2999(85)90752-6.
4
A metabolic interaction in vivo between cannabidiol and 1 -tetrahydrocannabinol.大麻二酚与1-四氢大麻酚在体内的代谢相互作用。
Br J Pharmacol. 1972 Jun;45(2):375-7. doi: 10.1111/j.1476-5381.1972.tb08092.x.
5
Changes in body temperature and oxygen consumption rate of conscious mice produced by intrahypothalamic and intracerebroventricular injections of delta 9-tetrahydrocannabinol.下丘脑内和脑室内注射Δ⁹-四氢大麻酚对清醒小鼠体温和耗氧率的影响。
Br J Pharmacol. 1982 Feb;75(2):409-14. doi: 10.1111/j.1476-5381.1982.tb08802.x.
6
Tolerance to the hypothermic effects of 9-tetrahydrocannabinol as a function of age in the chicken.鸡对9-四氢大麻酚低温效应的耐受性与年龄的关系。
Br J Pharmacol. 1973 Mar;47(3):452-6. doi: 10.1111/j.1476-5381.1973.tb08176.x.
7
Evidence for a bidirectional cross-tolerance between morphine and delta 9-tetrahydrocannabinol in mice.小鼠体内吗啡与δ9-四氢大麻酚之间双向交叉耐受性的证据。
Eur J Pharmacol. 1994 Jul 21;260(1):5-13. doi: 10.1016/0014-2999(94)90003-5.
8
The effects of (-)-delta9-tetrahydrocannabinol on reserpine-induced hypothermia in rats.(-)-δ9-四氢大麻酚对利血平诱导的大鼠体温过低的影响。
Br J Pharmacol. 1973 Oct;49(2):243-52. doi: 10.1111/j.1476-5381.1973.tb08369.x.
9
The distribution of delta1-tetrahydrocannabinol and 7-hydroxy-delta-tetrahydrocannabinol in the mouse brain after intraventricular injection.脑室注射后小鼠脑内δ1-四氢大麻酚和7-羟基-δ-四氢大麻酚的分布
J Pharm Pharmacol. 1973 Dec;25(12):948-52. doi: 10.1111/j.2042-7158.1973.tb09984.x.
10
Blood and brain levels of delta1-tetrahydrocannabinol in mice--the effect of 7-hydroxy-delta1-tetrahydrocannabinol.小鼠体内δ1-四氢大麻酚的血液及脑内水平——7-羟基-δ1-四氢大麻酚的影响
Biochem Pharmacol. 1974 Mar 15;23(6):1140-3. doi: 10.1016/0006-2952(74)90017-3.
引用本文的文献
1
Changes in body temperature and oxygen consumption rate of conscious mice produced by intrahypothalamic and intracerebroventricular injections of delta 9-tetrahydrocannabinol.下丘脑内和脑室内注射Δ⁹-四氢大麻酚对清醒小鼠体温和耗氧率的影响。
Br J Pharmacol. 1982 Feb;75(2):409-14. doi: 10.1111/j.1476-5381.1982.tb08802.x.
2
Effect of delta8-THC on alcohol-induced sleeping time in the rat.δ8-四氢大麻酚对大鼠酒精诱导睡眠时间的影响。
Psychopharmacologia. 1974;39(3):193-8. doi: 10.1007/BF00421026.
本文引用的文献
1
Activity of delta8- and delta9-tetrahydrocannabinol and related compounds in the mouse.δ8-和δ9-四氢大麻酚及相关化合物在小鼠体内的活性。
Science. 1971 Apr 9;172(3979):165-7. doi: 10.1126/science.172.3979.165.
2
A metabolic interaction in vivo between cannabidiol and 1 -tetrahydrocannabinol.大麻二酚与1-四氢大麻酚在体内的代谢相互作用。
Br J Pharmacol. 1972 Jun;45(2):375-7. doi: 10.1111/j.1476-5381.1972.tb08092.x.
3
Contribution of the metabolite 7-hydroxy-delta1-tetrahydrocannabinol towards the pharmacological activity of delta 1-tetrahydrocannabinol in mice.代谢物7-羟基-δ1-四氢大麻酚对δ1-四氢大麻酚在小鼠体内药理活性的贡献。
Biochem Pharmacol. 1973 Jan 15;22(2):175-84. doi: 10.1016/0006-2952(73)90271-2.
4
Distribution of radioactivity in brain of tolerant and nontolerant pigeons treated with 3 H- 9 -tetrahydrocannabinol.用³H-9-四氢大麻酚处理的耐受和非耐受鸽子大脑中的放射性分布。
Biochem Pharmacol. 1973 Feb 1;22(3):399-405. doi: 10.1016/0006-2952(73)90420-6.
5
Effect of repeated administration on the metabolism of (-)- 9 -tetrahydrocannabinols in rats.重复给药对大鼠体内（-）-9-四氢大麻酚代谢的影响。
Res Commun Chem Pathol Pharmacol. 1973 Jan;5(1):215-8.
6
Brain levels of 1 -tetrahydrocannabinol and its metabolites in mice--correlation with behaviour, and the effect of the metabolic inhibitors SKF 525A and piperonyl butoxide.小鼠脑中1-四氢大麻酚及其代谢物水平——与行为的相关性以及代谢抑制剂SKF 525A和胡椒基丁醚的作用
Biochem Pharmacol. 1972 Aug 15;21(16):2237-48. doi: 10.1016/0006-2952(72)90039-1.
7
Effect of cannabis and certain of its constituents on pentobarbitone sleeping time and phenazone metabolism.大麻及其某些成分对戊巴比妥睡眠时间和非那宗代谢的影响。
Br J Pharmacol. 1972 Feb;44(2):250-61.
8
The ring test: a quantitative method for assessing the 'cataleptic' effect of cannabis in mice.环形试验：一种评估大麻对小鼠“僵住症”效应的定量方法。
Br J Pharmacol. 1972 Dec;46(4):753-63. doi: 10.1111/j.1476-5381.1972.tb06900.x.
Zotero 插件