罗伊内酯衍生物的合成及其细胞毒性
Synthesis and Cytotoxicities of Royleanone Derivatives.
作者信息
Li Cheng-Ji, Xia Fan, Wu Rong, Tan Hong-Sheng, Xu Hong-Xi, Xu Gang, Qin Hong-Bo
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
出版信息
Nat Prod Bioprospect. 2018 Dec;8(6):453-456. doi: 10.1007/s13659-018-0173-y. Epub 2018 Jun 16.
Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11-C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro.
以鼠尾草酸为起始原料合成具有C11 - C14对醌结构的丹参酮衍生物。通过对丹参酮酸、丹参新醌甲和脱氧新隐丹参酮的细胞毒性试验验证了丹参酮衍生物C - 20基团的重要性。按照我们的合成路线，合成了15个酰胺衍生物，其中8个化合物在体外对三种人类癌细胞系表现出中等程度的细胞毒性活性。
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