przewalskin A：一种从丹参中分离得到的具有6/6/7碳环骨架的新型C23萜类化合物
Przewalskin A: A new C23 terpenoid with a 6/6/7 carbon ring skeleton from Salvia przewalskii maxim.
作者信息
Xu Gang, Hou Ai-Jun, Wang Rui-Rui, Liang Guang-Yu, Zheng Yong-Tang, Liu Ze-Yuan, Li Xiao-Li, Zhao Yu, Huang Sheng-Xiong, Peng Li-Yan, Zhao Qin-Shi
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PRC.
出版信息
Org Lett. 2006 Sep 28;8(20):4453-6. doi: 10.1021/ol061609t.
Przewalskin A (1), a novel C23 terpenoid with a 6/6/7 carbon ring skeleton, was isolated from Salvia przewalskii. Its structure was determined by comprehensive 1D NMR, 2D NMR, and MS spectroscopic analysis and subsequently confirmed by a single-crystal X-ray diffraction study of its PDC oxidation derivative (2). Compounds 1 and 2 showed modest anti-HIV-1 activity with EC50 = 41 and 89 microg/mL, respectively.
从甘西鼠尾草中分离出了 przewalskin A (1)，它是一种具有 6/6/7 碳环骨架的新型 C23 萜类化合物。通过综合一维核磁共振、二维核磁共振和质谱光谱分析确定了其结构，随后通过对其 PDC 氧化衍生物 (2) 的单晶 X 射线衍射研究进行了确认。化合物 1 和 2 显示出适度的抗 HIV-1 活性，EC50 分别为 41 和 89 μg/mL。
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