[南基伍省刚果患者主动脉根部近端扩张的患病率及其与左心室重构的关系：一项横断面研究]

[Prevalence of the proximal aortic root dilatation and it relationship with left ventricular remodelling among South-Kivu Congolese patients: A cross sectional study].

作者信息

Katchunga P, Kaishusha D, Mwambusa R, Mubalama E

机构信息

Clinique Saint-Luc-de-Bukavu, B.P 02, avenue des Martyrs, Bukavu, République démocratique du Congo; Observatoire des maladies non transmissibles, faculté de médecine, université Catholique de Bukavu, B.P 285, Bukavu, République démocratique du Congo.

Observatoire des maladies non transmissibles, faculté de médecine, université Catholique de Bukavu, B.P 285, Bukavu, République démocratique du Congo.

出版信息

Ann Cardiol Angeiol (Paris). 2018 Sep;67(4):250-255. doi: 10.1016/j.ancard.2018.03.001. Epub 2018 Jun 15.

DOI:10.1016/j.ancard.2018.03.001

PMID:29909952

Abstract

AIM

Studies of the influence of aortic root remodelling on the left ventricle are scarce in sub Saharan Africa even though this region has got high prevalence of arterial hypertension which is positively related to sinuses of Valsalva diameter. The present work aims to determine the frequency of the proximal aortic root enlargement and to evaluate its association with the left ventricle structure and function respectively among Congolese patients.

METHOD

Four hundreds and three (403) patients who realised transthoracic cardiac echography were recruited. The association between the proximal aortic root diameter and the left ventricular echocardiographic parameters was modelised in a multiple linear regression using the Stepwise method.

RESULTS

Among the 403 patients, 69.4% were hypertensive. A multivariate linear regression analysis showed correlations between the proximal aortic root diameter and the left ventricular mass (β=1.12; P=0.01), the left ventricular diastolic diameter (β=0.26, P=0.001) and the E/A ratio (β=-0.02; P<0.0001) respectively. The independent predictor of the proximal aortic root diameter were age (β=0.06, P=0.0006), duration of arterial hypertension (β=0.11, P=0.002) and diastolic blood pressure (β=0.03; P=0.02). The frequency of the proximal aortic root dilatation was 3.5%.

CONCLUSION

These results infancies the importance of including the proximal aortic root dilatation as specific infra clinic risk factor among Congolese.

摘要

目的

尽管撒哈拉以南非洲地区动脉高血压患病率很高，且其与主动脉瓣窦直径呈正相关，但该地区关于主动脉根部重塑对左心室影响的研究却很少。本研究旨在确定刚果患者中近端主动脉根部扩大的发生率，并分别评估其与左心室结构和功能的关系。

方法

招募了403例接受经胸心脏超声检查的患者。采用逐步法进行多元线性回归，建立近端主动脉根部直径与左心室超声心动图参数之间的关联模型。

结果

在403例患者中，69.4%为高血压患者。多元线性回归分析显示，近端主动脉根部直径分别与左心室质量（β=1.12；P=0.01）、左心室舒张直径（β=0.26，P=0.001）和E/A比值（β=-0.02；P<0.0001）相关。近端主动脉根部直径的独立预测因素为年龄（β=0.06，P=0.0006）、动脉高血压病程（β=0.11，P=0.002）和舒张压（β=0.03；P=0.02）。近端主动脉根部扩张的发生率为3.5%。