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在材料的苯并噻吩基组分的便捷合成中，亚砜导向的无金属交叉偶联反应。

Sulfoxide-directed metal-free cross-couplings in the expedient synthesis of benzothiophene-based components of materials.

作者信息

Eberhart Andrew J, Shrives Harry, Zhang Yuntong, Carrër Amandine, Parry Adam V S, Tate Daniel J, Turner Michael L, Procter David J

机构信息

School of Chemistry , University of Manchester , Oxford Rd , Manchester , M13 9PL , UK . Email:

出版信息

Chem Sci. 2016 Feb 1;7(2):1281-1285. doi: 10.1039/c5sc03823e. Epub 2015 Nov 9.

DOI:10.1039/c5sc03823e
PMID:29910885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5975836/
Abstract

A metal-free approach combining sulfoxide-directed metal-free C-H cross-couplings with tuneable electrophile-mediated heterocyclizations and carbocyclative dimerizations, allows expedient access to benzothiophene-based systems that are components of important materials or are proven organic materials in their own right. As benzothiophene-based materials are typically prepared using Pd-catalyzed cross-coupling processes, our approach allows potential issues of metal cost and supply, and metal-contamination of products, to be avoided.

摘要

一种无金属方法，将亚砜导向的无金属C-H交叉偶联与可调亲电试剂介导的杂环化和碳环化二聚反应相结合，能够便捷地合成基于苯并噻吩的体系，这些体系是重要材料的组成部分，或者本身就是经过验证的有机材料。由于基于苯并噻吩的材料通常使用钯催化的交叉偶联过程制备，我们的方法可以避免金属成本和供应以及产品金属污染等潜在问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c67/5975836/c55396586264/c5sc03823e-s7.jpg
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