Department of Chemistry, University at Albany, State University of New York, 1400 Washington Ave, Albany, NY 12222, USA.
Chem Commun (Camb). 2018 Jul 11;54(54):7443-7446. doi: 10.1039/c8cc03575j. Epub 2018 Jun 18.
The development of visible-light-induced synthesis of functionalized pyrroloindolines via a radical cascade reaction is reported. The reaction shows a broad substrate scope and highlights the mild nature of the reaction conditions. A range of substitutions on indole aromatic rings and N-centers is well tolerated, including a free allylic alcohol. Relying on the strategy, a rapid synthesis of (±)-flustraminol B was achieved.
本文报道了可见光诱导的通过自由基级联反应合成功能化吡咯并吲哚啉的方法。该反应具有广泛的底物范围，并突出了反应条件的温和性。吲哚芳环和 N-中心的各种取代基都能很好地耐受，包括游离烯丙醇。该策略还实现了（±）-flustraminol B 的快速合成。
