Induced type-B reticulum cell neoplasia of CBA mice. II. Functional similarities between tumorigenic reticulum cells and normal accessory cells.

In a previous report, it was proposed on the basis of phenotypic evidence that the population of transplantable cells which constituted the major component of experimentally induced type-B reticulum cell neoplasms of CBA strain mice could be a neoplastic counterpart of lymphoid dendritic or veiled accessory cells. This has been further tested by an in vitro examination of their accessory function. Both similarities and differences in behaviour between the neoplastic cells and accessory cells prepared from spleens of normal mice were found. The possible significance of these properties is discussed in relation to the process of neoplastic change.