Department of Animal Science, Iowa State University, Ames, IA.
J Anim Sci. 2018 Sep 7;96(9):3897-3905. doi: 10.1093/jas/sky246.
To evaluate the effects of a Saccharomyces cerevisiae fermentation product (SCFP; Original XPC, Diamond V, Cedar Rapids, IA) on growth performance and antioxidant defense of newly weaned beef cattle, 180 single-source steers (278 ± 21 kg; SD) were used in a 56-d receiving study. Seven days after arrival, steers were blocked by body weight (BW) to pens of 6 and randomly assigned to treatments: SCFP at 0 (CON), 14 (SCFP14), or 28 (SCFP28) g·steer-1·d-1. Pen was the experimental unit (n = 10 per treatment). On day 0, steers were boostered against Bovine Viral Diarrhea Virus (BVDV) Type 1 and 2 (Vista Once, Merck, Madison, NJ). Weights were collected on days 1, 0, 14, 27, 42, 55, and 56. One steer per pen was bled on days 0, 14, 27, 42, and 56 for analysis of BVDV antibody titers; blood from days 0, 27, and 56 was analyzed for red blood cell lysate superoxide dismutase (SOD) activity and glutathione (total = tGSH, oxidized = GSSG, and reduced = GSH) concentrations, plasma malondialdehyde (MDA) concentrations, and serum lysozyme activity. Performance and blood data were analyzed as a randomized complete block design using Proc Mixed of SAS with fixed effects of treatment and block and random effect of pen. Linear and quadratic contrast statements were used. Antibody titers were log transformed and analyzed as repeated measures. There were no treatment by day interactions (P ≥ 0.16), and no linear or quadratic effects of SCFP on feedlot performance, antibody titers, or lysozyme activity (P > 0.10). Day 27 MDA concentrations tended to linearly increase (P = 0.09). A quadratic effect of SCFP on day 56 SOD activity (P = 0.004) was driven by lesser activity for SCFP14-fed steers. On day 27, a tendency for a quadratic effect of SCFP (P = 0.09) on GSH was driven by greater concentrations for SCFP14-fed steers resulting in a lesser GSSG:GSH ratio (P = 0.05). Greater GSH for SCFP14-fed steers caused a tendency for a quadratic effect on day 56 (P = 0.07); however, this did not result in an effect of SCFP on the GSSG:GSH ratio (P ≥ 0.25). A tendency for a linear effect of SCFP on tGSH was noted on day 56 (P = 0.09). Morbidity data were analyzed using Proc Glimmix of SAS. There was a quadratic effect of SCFP on percentage of respiratory treatments prior to day 14 (P = 0.04). These results could indicate lesser levels of oxidative stress for steers receiving SCFP at 14 vs. 0 or 28 g/d. Under the conditions of this study, no performance benefit of SCFP was noted.
为了评估酿酒酵母发酵产物（SCFP；原始 XPC，Diamond V，Cedar Rapids，IA）对新断奶肉牛生长性能和抗氧化防御的影响，180 头单源公牛（278±21kg；SD）进行了为期 56 天的接收研究。到达后第 7 天，根据体重（BW）将牛分组到 6 个栏中，并随机分配到以下处理组：SCFP 为 0（CON）、14（SCFP14）或 28（SCFP28）g·牛-1·d-1。栏为实验单位（每个处理 10 头）。在第 0 天，牛接受了牛病毒性腹泻病毒（BVDV）1 型和 2 型（Vista Once，Merck，Madison，NJ）的加强免疫。在第 1、0、14、27、42、55 和 56 天收集体重。每栏一头牛在第 0、14、27、42 和 56 天采血，用于分析 BVDV 抗体滴度；第 0、27 和 56 天的血液用于分析红细胞溶血物超氧化物歧化酶（SOD）活性和谷胱甘肽（总= tGSH、氧化= GSSG、还原= GSH）浓度、血浆丙二醛（MDA）浓度和血清溶菌酶活性。使用 SAS 的 Proc Mixed 程序以处理和块的固定效应和栏的随机效应分析性能和血液数据。使用线性和二次对比语句。抗体滴度经过对数转换，作为重复测量进行分析。处理与天数之间没有交互作用（P≥0.16），SCFP 对肥育性能、抗体滴度或溶菌酶活性没有线性或二次影响（P＞0.10）。第 27 天 MDA 浓度呈线性增加趋势（P=0.09）。SCFP 对第 56 天 SOD 活性的二次效应（P=0.004）是由 SCFP14 组牛的活性降低引起的。第 27 天，SCFP 对 GSH 的二次效应（P=0.09）呈趋势，原因是 SCFP14 组牛的 GSH 浓度较高，导致 GSSG:GSH 比值降低（P=0.05）。SCFP14 组牛的 GSH 较高导致第 56 天出现二次效应趋势（P=0.07）；然而，这并没有导致 SCFP 对 GSSG:GSH 比值产生影响（P≥0.25）。第 56 天注意到 SCFP 对总 GSH 的线性效应呈趋势（P=0.09）。发病率数据使用 SAS 的 Proc Glimmix 进行分析。在第 14 天之前，SCFP 对呼吸治疗的百分比有二次影响（P=0.04）。这些结果可能表明，与 0 或 28 g/d 的 SCFP 相比，接受 14 g/d SCFP 的牛的氧化应激水平较低。在本研究条件下，未发现 SCFP 对性能有有益影响。
