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人类抗利尿激素基因与催产素基因相连，并在一种培养的肺癌细胞系中选择性表达。

The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line.

作者信息

Sausville E, Carney D, Battey J

出版信息

J Biol Chem. 1985 Aug 25;260(18):10236-41.

PMID:2991279
Abstract

The human genes for prepro-arginine-vasopressin-neurophysin II (prepro-AVP-NPII) and prepro-oxytocin-neurophysin I (prepro-OT-NPI) were cloned from a human genomic library and the nucleotide sequence of both genes was determined. The two genes are similar in their intron-exon structure, linked together with 12 kilobases intervening, and transcribed from opposite DNA strands. A human small cell lung cancer cell line, H378, produces significant quantities of pre-pro-AVP-NPII mRNA using a transcription unit predicted from the genomic DNA sequence. Despite the proximity of the actively transcribed prepro-AVP-NPII gene, transcription of prepro-OT-NPI is not detected in this cell line.

摘要

从人类基因组文库中克隆了前体-精氨酸加压素-神经垂体素II（prepro-AVP-NPII）和前体-催产素-神经垂体素I（prepro-OT-NPI）的人类基因，并测定了这两个基因的核苷酸序列。这两个基因的内含子-外显子结构相似，中间间隔12千碱基相连，且从相反的DNA链转录。一种人类小细胞肺癌细胞系H378，利用从基因组DNA序列预测的转录单元产生大量的前体-AVP-NPII mRNA。尽管活跃转录的前体-AVP-NPII基因距离很近，但在该细胞系中未检测到前体-OT-NPI的转录。

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The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line.人类抗利尿激素基因与催产素基因相连，并在一种培养的肺癌细胞系中选择性表达。
J Biol Chem. 1985 Aug 25;260(18):10236-41.
2
Linkage relationships of human arginine vasopressin-neurophysin-II and oxytocin-neurophysin-I to prodynorphin and other loci on chromosome 20.人精氨酸加压素-神经垂体素-II和催产素-神经垂体素-I与强啡肽原及20号染色体上其他基因座的连锁关系。
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Provasopressin-neurophysin II processing is cell-specific in heterologous cell lines expressing a metallothionein-vasopressin fusion gene.在表达金属硫蛋白-加压素融合基因的异源细胞系中，血管加压素-神经垂体素II的加工具有细胞特异性。
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The pituitary hormones arginine vasopressin-neurophysin II and oxytocin-neurophysin I show close linkage with interleukin-1 on mouse chromosome 2.垂体激素精氨酸加压素-神经垂体素II和催产素-神经垂体素I在小鼠2号染色体上与白细胞介素-1显示出紧密连锁。
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