费城染色体阳性淋巴细胞淋巴瘤——它是罕见还是诊断不足？
Philadelphia chromosome-positive lymphoblastic lymphoma-Is it rare or underdiagnosed?
作者信息
Alshomar Ahmad, El Fakih Riad
机构信息
Medicine Department, College of Medicine, Qassim University, Saudi Arabia; Adult Hematology, Bone Marrow Transplantation, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Adult Hematology, Bone Marrow Transplantation, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
出版信息
Hematol Oncol Stem Cell Ther. 2020 Dec;13(4):242-243. doi: 10.1016/j.hemonc.2018.05.007. Epub 2018 Jun 15.
Lymphoblastic lymphomas (LBLs) are neoplasms of precursor B and T cells; they are considered in the same spectrum as precursor B and T cell acute lymphoblastic leukemia (ALL). The World Health Organization classification classifies both LBL and ALL as one disease entity. While chromosome abnormalities are well defined with all of their therapeutic and prognostic implications in ALL, these are not well studied in LBL. Here, we describe a case of Philadelphia chromosome-positive LBL and review the available literature regarding this entity.
淋巴母细胞淋巴瘤（LBL）是前体B细胞和T细胞的肿瘤；它们与前体B细胞和T细胞急性淋巴细胞白血病（ALL）被视为同一谱系。世界卫生组织分类将LBL和ALL都归类为一种疾病实体。虽然在ALL中染色体异常及其所有治疗和预后意义都已明确，但在LBL中对这些方面的研究并不充分。在此，我们描述一例费城染色体阳性的LBL病例，并回顾有关该实体的现有文献。
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