University of Kragujevac, Faculty of Medicine, Kragujevac, Serbia.
Pathol Res Pract. 2012 Jul 15;208(7):420-3. doi: 10.1016/j.prp.2012.04.007. Epub 2012 May 31.
A 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q- after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia. Immunophenotyping of peripheral blood by flow cytometry showed HLA-DR, CD34, CD19, CD22, CD10, CD33, and CD11b positivity. Cytogenetic analysis revealed the presence of 20q- and Philadelphia chromosome t(9;22)(q34:q11) at the time of disease transformation to ALL. The JAK2V617F mutation was not found. This is a very rare case of simultaneous presence of two cytogenetics abnormalities and evolution of primary idiopathic myelofibrosis to Philadelphia-positive acute lymphoblastic leukemia.
一位 56 岁的男性患有慢性特发性骨髓纤维化，细胞遗传学发现 20q-，经过 10 个月后发展为急性费城阳性淋巴母细胞白血病。流式细胞术检测外周血免疫表型显示 HLA-DR、CD34、CD19、CD22、CD10、CD33 和 CD11b 阳性。细胞遗传学分析显示疾病转化为 ALL 时存在 20q-和费城染色体 t(9;22)(q34:q11)。未发现 JAK2V617F 突变。这是一个非常罕见的同时存在两种细胞遗传学异常和原发性特发性骨髓纤维化向费城阳性急性淋巴母细胞白血病演变的病例。
