未经治疗的艾迪生病患者血清血管紧张素转换酶水平升高。

High serum levels of angiotensin-converting enzyme in untreated Addison's disease.

作者信息

Falezza G, Lechi Santonastaso C, Parisi T, Muggeo M

出版信息

J Clin Endocrinol Metab. 1985 Sep;61(3):496-8. doi: 10.1210/jcem-61-3-496.

Abstract

Serum angiotensin-converting enzyme (ACE) in four patients with untreated Addison's disease was significantly higher [79.7 +/- 17.5 (SD) nmol min-1 ml-1] than in normal subjects (37.7 +/- 8.9 nmol min-1 ml-1, P less than 0.02). During corticosteroid hormone replacement therapy the enzyme levels returned within the normal range (44.0 +/- 7.6 nmol min-1 ml-1). In two additional patients the enzyme was assayed only while they were receiving therapy and found normal (38 and 52 nmol min-1 ml-1, respectively). In one of them, an increase ACE level (70 nmol min-1 ml-1) was found after therapy was reduced by 50%. Primary adrenal insufficiency is another disease in which ACE levels may be increased.

摘要

4例未经治疗的艾迪生病患者的血清血管紧张素转换酶（ACE）水平[79.7±17.5（标准差）nmol·min⁻¹·ml⁻¹]显著高于正常受试者（37.7±8.9 nmol·min⁻¹·ml⁻¹，P<0.02）。在皮质类固醇激素替代治疗期间，酶水平恢复到正常范围内（44.0±7.6 nmol·min⁻¹·ml⁻¹）。另外2例患者仅在接受治疗时检测了该酶，结果发现正常（分别为38和52 nmol·min⁻¹·ml⁻¹）。其中1例患者在治疗剂量减少50%后，ACE水平升高（70 nmol·min⁻¹·ml⁻¹）。原发性肾上腺功能不全是另一种可能导致ACE水平升高的疾病。