结节病和其他肉芽肿性疾病中的血清血管紧张素转换酶（SACE）
Serum angiotensin--converting enzyme (SACE) in sarcoidosis and other granulomatous disorders.
作者信息
Studdy P, James D G, Sherlock S
出版信息
Trans Med Soc Lond. 1978;95:54-9.
Serum angiotensin-converting enzyme (SACE) activity was significantly higher in 90 patients with sarcoidosis (55 +/- [S.D.] 23 nmol min-1 ml-1) than in 80 healthy controls (34 +/- 9 nmol min-1 ml-1). Steroid therapy modified SACE activity; 60 sarcoidosis patients who were not being treated with steroids had significantly higher enzyme activities (58 +/- 24 nmol min-1 ml-1) than 30 steroid-treated sarcoidosis patients (40 +/- 19 nmol min-1 ml-1). In 50% of the non-steroid treated sarcoidosis patients SACE activity was more than than 2 S.D. above the mean value for the controls. SACE activity was measured in 22 tuberculous patients (38 +/- 14 nmol min-1 ml-1), 20 leprosy patients (34 +/- 9 nmol min-1 ml-1), 31 with primary biliary cirrhosis (44 +/- 20 nmol min-1 ml-1), 26 with inflammatory bowel disease (31 +/- 9 nmol min-1 ml-1), eight with hepatic granulomatous disease, five with Hodgkin's disease, and two with schistosomiasis. The combined false-positive rate for these non-sarcoidosis patients was 10%. Serial SACE assays provide useful information on the course of sarcoidosis and response to steroid treatment.
90例结节病患者的血清血管紧张素转换酶（SACE）活性（55±[标准差]23 nmol·min⁻¹·ml⁻¹）显著高于80例健康对照者（34±9 nmol·min⁻¹·ml⁻¹）。类固醇疗法改变了SACE活性；60例未接受类固醇治疗的结节病患者的酶活性（58±24 nmol·min⁻¹·ml⁻¹）显著高于30例接受类固醇治疗的结节病患者（40±19 nmol·min⁻¹·ml⁻¹）。在50%未接受类固醇治疗的结节病患者中，SACE活性比对照者的平均值高出2个标准差以上。对22例结核病患者（38±14 nmol·min⁻¹·ml⁻¹）、20例麻风病患者（34±9 nmol·min⁻¹·ml⁻¹）、31例原发性胆汁性肝硬化患者（44±20 nmol·min⁻¹·ml⁻¹）、26例炎症性肠病患者（31±9 nmol·min⁻¹·ml⁻¹）、8例肝肉芽肿病患者、5例霍奇金病患者和2例血吸虫病患者进行了SACE活性检测。这些非结节病患者的联合假阳性率为10%。连续进行SACE检测可提供有关结节病病程及对类固醇治疗反应的有用信息。
Zotero 插件