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创伤后慢性疼痛患者——创伤后应激障碍(PTSD)的患病率以及转介至疼痛康复机构的两个斯堪的纳维亚样本中的疼痛敏化情况。

The traumatised chronic pain patient-Prevalence of posttraumatic stress disorder - PTSD and pain sensitisation in two Scandinavian samples referred for pain rehabilitation.

作者信息

Andersen Tonny Elmose, Andersen Per Grünwald, Vakkala Merja Annika, Elklit Ask

机构信息

Department of Psychology, University of Southern Denmark, Odense, Denmark.

Anesthesia-Intensive Care and Pain Center South, Odense University Hospital, Odense, Denmark.

出版信息

Scand J Pain. 2012 Jan 1;3(1):39-43. doi: 10.1016/j.sjpain.2011.10.001.

DOI:10.1016/j.sjpain.2011.10.001
PMID:29913766
Abstract

UNLABELLED

Introduction Correctly identifying chronic pain patients with posttraumatic stress disorder (PTSD) is important because the comorbidity of a chronic pain condition and PTSD is found to compromise treatment success. In addition, the existence of PTSD is associated with pain sensitisation, elevated levels of pain, and disability. Furthermore, the diagnostic criteria for PTSD has changed dramatically in the last two decades which has had a profound impact on the reported prevalence rates of PTSD in chronic pain samples. To our knowledge, no study has employed the DSM-IV criteria for estimating the prevalence of PTSD in chronic pain patients referred consecutively for multidisciplinary pain rehabilitation. Aim The aim of the present study was to assess the prevalence of significant traumatic stressors and PTSD in chronic pain patients referred consecutively to multidisciplinary pain rehabilitation. We wanted to investigate whether specific pain diagnoses were more related to PTSD than others. Moreover, we investigated the possible association of altered sensory processing (hypersensitivity or hyposensitivity) and PTSD. Methods Data were collected from two Scandinavian multidisciplinary pain centres (Denmark and Finland). All patients referred consecutively were assessed for PTSD and sensitisation at admission. A total of 432 patients were assessed, of which 304 (DK, N =220, female n = 144; FIN, N=84, female n = 44) were admitted and consented to participate. All patients had to be diagnosed with a non-malign chronic pain condition lasting for at least 6 months (median = 6.0 years). The Harvard Trauma Questionnaire was employed to measure PTSD symptoms, using the DSM-IV criteria. To measure altered sensory processing, anaesthetists performed quantitative sensory testing on admission. Patients were asked to report if cold, brush, and pinprick mechanical stimulation resulted in decreased or increased sensation or pain. Results stimulation resulted in decreased or increased sensation or pain.

RESULTS

A high prevalence of PTSD was found in both consecutive samples. Using the DSM-IV criteria, 23% fulfilled the criteria for a possible PTSD diagnosis. There were no gender differences in PTSD. The three most reported traumatic events: traffic accidents, serious illness personally or in the family, and the actual loss of someone, were reported as the primary traumatic events by almost 50% of those with PTSD. No particular pain diagnosis was significantly related to PTSD. However, hypersensitivity to cold and hyposensitivity to brush were significantly associated with PTSD. Discussion The prevalence of PTSD in the present study was 23%. Earlier studies finding a lower prevalence rate of PTSD may reflect the use of older diagnostic criteria for PTSD or other estimates, for instance PTSD symptom cut-off scores. Conclusion The study emphasised the importance of screening all chronic pain patients for PTSD at admission for pain rehabilitation, using up to date diagnostic tools. Implications Untreated PTSD may exacerbate or maintain the pain condition and negatively affect outcome of pain rehabilitation.

摘要

未标注

引言 正确识别患有创伤后应激障碍(PTSD)的慢性疼痛患者很重要,因为发现慢性疼痛状况与PTSD的共病会影响治疗效果。此外,PTSD的存在与疼痛敏感化、疼痛水平升高和残疾有关。此外,在过去二十年中,PTSD的诊断标准发生了巨大变化,这对慢性疼痛样本中报道的PTSD患病率产生了深远影响。据我们所知,尚无研究采用《精神疾病诊断与统计手册》第四版(DSM-IV)标准来估计连续转诊接受多学科疼痛康复治疗的慢性疼痛患者中PTSD的患病率。目的 本研究的目的是评估连续转诊接受多学科疼痛康复治疗的慢性疼痛患者中重大创伤性应激源和PTSD的患病率。我们想调查特定的疼痛诊断是否比其他诊断与PTSD的相关性更强。此外,我们研究了感觉处理改变(过敏或感觉减退)与PTSD之间的可能关联。方法 数据收集自两个斯堪的纳维亚多学科疼痛中心(丹麦和芬兰)。所有连续转诊的患者在入院时均接受PTSD和敏感化评估。共评估了432例患者,其中304例(丹麦,N = 220,女性n = 144;芬兰,N = 84,女性n = 44)入院并同意参与。所有患者必须被诊断患有持续至少6个月(中位数 = 6.0年)的非恶性慢性疼痛疾病。采用哈佛创伤问卷,依据DSM-IV标准测量PTSD症状。为测量感觉处理改变,麻醉师在入院时进行定量感觉测试。要求患者报告冷、刷和针刺机械刺激是否导致感觉或疼痛降低或增加。结果 刺激导致感觉或疼痛降低或增加。

结果

在两个连续样本中均发现PTSD的高患病率。采用DSM-IV标准,23%的患者符合可能的PTSD诊断标准。PTSD在性别上无差异。报告最多的三个创伤性事件:交通事故、本人或家人患重病以及亲人离世,几乎50%的PTSD患者将其报告为主要创伤性事件。没有特定的疼痛诊断与PTSD有显著相关性。然而,对冷过敏和对刷感觉减退与PTSD显著相关。讨论 本研究中PTSD的患病率为23%。早期研究发现PTSD患病率较低可能反映了使用了较旧的PTSD诊断标准或其他评估方法,例如PTSD症状截断分数。结论 该研究强调了在疼痛康复入院时使用最新诊断工具对所有慢性疼痛患者进行PTSD筛查的重要性。意义 未经治疗的PTSD可能会加重或维持疼痛状况,并对疼痛康复结果产生负面影响。

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