Baker B I, Bird D J, Buckingham J C
J Endocrinol. 1985 Aug;106(2):R5-8. doi: 10.1677/joe.0.106r005.
Melanin-concentrating hormone (MCH) is a neural peptide associated with colour change in fishes. We show here that it also inhibits corticotrophin (ACTH) secretion. Synthetic salmonid MCH at a concentration of 100pmol/l reduced the in-vitro release of ACTH by pars distales (pDs) taken from stressed trout. At lower concentrations (10pmol/l) the peptide inhibited CRF-41-induced secretion of ACTH by pDs removed from unstressed trout, while at higher concentrations (10nmol/l) it reduced the corticotrophic response of rat pituitary tissue to CRF-41.
黑色素浓缩激素（MCH）是一种与鱼类颜色变化相关的神经肽。我们在此表明，它还能抑制促肾上腺皮质激素（ACTH）的分泌。浓度为100pmol/l的合成鲑科鱼类MCH可降低应激虹鳟鱼远侧部（pDs）体外释放的ACTH。在较低浓度（10pmol/l）时，该肽可抑制从未应激虹鳟鱼取出的pDs对CRF - 41诱导的ACTH分泌，而在较高浓度（10nmol/l）时，它可降低大鼠垂体组织对CRF - 41的促肾上腺皮质反应。
