下丘脑的发育：保守、修饰与创新
Development of the hypothalamus: conservation, modification and innovation.
作者信息
Xie Yuanyuan, Dorsky Richard I
机构信息
Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84112, USA.
Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84112, USA
出版信息
Development. 2017 May 1;144(9):1588-1599. doi: 10.1242/dev.139055.
Abstract
The hypothalamus, which regulates fundamental aspects of physiological homeostasis and behavior, is a brain region that exhibits highly conserved anatomy across vertebrate species. Its development involves conserved basic mechanisms of induction and patterning, combined with a more plastic process of neuronal fate specification, to produce brain circuits that mediate physiology and behavior according to the needs of each species. Here, we review the factors involved in the induction, patterning and neuronal differentiation of the hypothalamus, highlighting recent evidence that illustrates how changes in Wnt/β-catenin signaling during development may lead to species-specific form and function of this important brain structure.
摘要
下丘脑调节生理稳态和行为的基本方面，是一个在脊椎动物物种中具有高度保守解剖结构的脑区。其发育涉及保守的诱导和模式形成基本机制，以及更具可塑性的神经元命运特化过程，以产生根据每个物种需求介导生理和行为的脑回路。在这里，我们综述了参与下丘脑诱导、模式形成和神经元分化的因素，强调了最近的证据，这些证据说明了发育过程中Wnt/β-连环蛋白信号的变化如何可能导致这个重要脑结构的物种特异性形式和功能。
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