瞬时受体电位通道M4（TRPM4通道）在心血管生理与病理生理中的作用
Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology.
作者信息
Wang Chen, Naruse Keiji, Takahashi Ken
机构信息
Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
出版信息
Cells. 2018 Jun 15;7(6):62. doi: 10.3390/cells7060062.
Abstract
The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also plays a key role in cardiovascular pathophysiology; for example, a mutation in the TRPM4 channel leads to cardiac conduction disease. Recently, it has been suggested that the TRPM4 channel is also involved in the development of cardiac ischemia-reperfusion injury, which causes myocardial infarction. In the present review, we discuss the physiological function of the TRPM4 channel, and assess its role in cardiovascular pathophysiology.
摘要
瞬时受体电位阳离子通道M亚家族成员4（TRPM4）通道在许多生理活动中影响钙稳态，如胰岛素分泌、免疫反应、呼吸反应和脑血管收缩。这种钙激活的单价选择性阳离子通道在心血管病理生理学中也起着关键作用；例如，TRPM4通道的突变会导致心脏传导疾病。最近，有人提出TRPM4通道也参与了导致心肌梗死的心脏缺血再灌注损伤的发展。在本综述中，我们讨论了TRPM4通道的生理功能，并评估了其在心血管病理生理学中的作用。
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