及它们在 RKO 细胞中的抗迁移活性的化学成分。
Chemical constituents of and their antimigratory activities in RKO cells.
机构信息
School of Pharmacy, Anhui University of Chinese Medicine , Hefei , P.R. China.
Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement , Hefei , P.R. China.
出版信息
Nat Prod Res. 2019 Dec;33(24):3493-3499. doi: 10.1080/14786419.2018.1484463. Epub 2018 Jun 18.
Two new sesquiterpenoids, curkwangsien A-B (-), and seven known compounds (-) were isolated from rhizomes of . Their structures were elucidated by spectroscopic analysis, and the absolute configurations of compounds - were determined by the quantum chemical ECD calculations. Compounds - are firstly reported from this plant. In the assays, compound was found to inhibit human colon cancer RKO cell migration in time-dependent manner.
从根茎中分离得到了两个新的倍半萜类化合物 curkwangsien A-B（-）和七个已知化合物（-）。通过光谱分析阐明了它们的结构，并用量子化学ECD 计算确定了化合物 - 的绝对构型。化合物 - 是首次从该植物中分离得到的。在 测定中，发现化合物 呈时间依赖性地抑制人结肠癌细胞 RKO 的迁移。
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