Chen Jih-Jung, Tsai Tung-Han, Liao Hsiang-Ruei, Chen Li-Chai, Kuo Yueh-Hsiung, Sung Ping-Jyun, Chen Chun-Lin, Wei Chun-Sheng
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan.
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
Molecules. 2016 Oct 17;21(10):1385. doi: 10.3390/molecules21101385.
Two new sesquiterpenoids-13-hydroxycurzerenone () and 1-oxocurzerenone ()-have been isolated from the rhizomes of , together with 13 known compounds (-). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 13-hydroxycurzerenone (), 1-oxocurzerenone (), curzerenone (), germacrone (), curcolone (), procurcumenol (), ermanin (), curcumin (), and a mixture of stigmast-4-en-3,6-dione () and stigmasta-4,22-dien-3,6-dione () exhibited inhibition (with inhibition % in the range of 21.28%-67.58%) against collagen-induced platelet aggregation at 100 μM. Compounds , , , , and the mixture of and inhibited arachidonic acid (AA)-induced platelet aggregation at 100 μM with inhibition % in the range of 23.44%-95.36%.
从[植物名称]的根茎中分离出了两种新的倍半萜类化合物——13-羟基莪术烯酮（）和1-氧代莪术烯酮（），以及13种已知化合物（-）。通过光谱分析和质谱分析确定了这两种新化合物的结构。在分离出的化合物中，13-羟基莪术烯酮（）、1-氧代莪术烯酮（）、莪术烯酮（）、吉马酮（）、莪术二酮（）、原莪术醇（）、榄香脂素（）、姜黄素（）以及豆甾-4-烯-3,6-二酮（）和豆甾-4,22-二烯-3,6-二酮（）的混合物在100 μM时对胶原诱导的血小板聚集表现出抑制作用（抑制率在21.28% - 67.58%范围内）。化合物，，，以及和的混合物在100 μM时对花生四烯酸（AA）诱导的血小板聚集有抑制作用，抑制率在23.44% - 95.36%范围内。
