Ghaderi Fereshteh, Samim Hossein, Keihanian Faeze, Danesh Sani Seyed Ali
Fellowship in echocardiography, Cardiology Department, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Cardiology Resident, Cardiology Department, Faculty of Medicine, Imam Reza and Ghaem Hospitals, Mashhad University of Medical Sciences, Shariati Square, Mashhad, Iran.
BMC Cardiovasc Disord. 2018 Jun 19;18(1):121. doi: 10.1186/s12872-018-0854-9.
It is well recognized that cardio- vascular risk factors lead to histological and functional changes in aorta, and aortic stiffness is the best predictor of cardiovascular morbidity and mortality. In this study we evaluated the relation of a less evaluated echocardiographic parameter of aortic stiffness, aortic propagation velocity (APV) with the presence and severity of CAD.
This cross sectional study was conducted from May 2015 to March 2016 in Imam Reza hospital, Mashhad, Iran. Seventy patients who were referred for elective coronary artery angiography were enrolled. Patients were divided into two sub-groups based on angiographic findings: patients with CAD (38 patients, 54.3%) and non-CAD (32 patients, 45.7%). Transthoracic echocardiography was performed using the conventional 2D and color M-Mode imaging. Aortic propagation velocity (APV), aortic strain (AS) and distensibility (AD) were measured. The presence and Severity of CAD (assessing by syntax score) and their relation with aortic stiffness indices were assessed.
Aortic strain (6.23 ± 1.93% versus 11.66 ± 4.86%, P < 0.0001), distensibility (2.46 ± 0.91 vs 5.57 ± 2.25 cm 2 dyn-110-3, P < 0.0001) and APV (48.63 ± 10.31 cm/sec vs 77.75 ± 9.97 cm/s, P < 0.0001) were significantly decreased in CAD group compared with non-CAD group. In our study, APV showed significant inverse relationship with CAD. Based on our results, APV less than 56 cm/sec could be used to predict CAD with sensitivity and specificity of 96.9 and 78.9% respectively. We also found an inverse correlation between APV and severity of CAD.
Aortic strain, AD and APV (a less evaluated echocardiographic index) showed significant inverse correlation with presence and severity of CAD.
众所周知，心血管危险因素会导致主动脉的组织学和功能改变，而主动脉僵硬度是心血管发病率和死亡率的最佳预测指标。在本研究中，我们评估了一个较少被评估的主动脉僵硬度超声心动图参数——主动脉传播速度（APV）与冠心病的存在及严重程度之间的关系。
本横断面研究于2015年5月至2016年3月在伊朗马什哈德的伊玛目·礼萨医院进行。纳入了70例因择期冠状动脉造影而转诊的患者。根据血管造影结果将患者分为两个亚组：冠心病患者（38例，54.3%）和非冠心病患者（32例，45.7%）。采用传统二维和彩色M型成像进行经胸超声心动图检查。测量主动脉传播速度（APV）、主动脉应变（AS）和扩张性（AD）。评估冠心病的存在及严重程度（通过句法评分评估）及其与主动脉僵硬度指标的关系。
与非冠心病组相比，冠心病组的主动脉应变（6.23±1.93%对11.66±4.86%，P<0.0001）、扩张性（2.46±0.91对5.57±2.25cm²dyn⁻¹10⁻³，P<0.0001）和APV（48.63±10.31cm/秒对77.75±9.97cm/秒，P<0.0001）显著降低。在我们的研究中，APV与冠心病呈显著负相关。根据我们的结果，APV小于56cm/秒可用于预测冠心病，敏感性和特异性分别为96.9%和78.9%。我们还发现APV与冠心病严重程度呈负相关。
主动脉应变、AD和APV（一个较少被评估的超声心动图指标）与冠心病的存在及严重程度呈显著负相关。
