Master of Public Health Program, Department of Population Health, University of North Dakota, 1301 North Columbia Rd. Stop 9037, Grand Forks, ND, 58202, USA.
Department of Public Policy, Vanderbilt University School of Medicine, 2525 West End Ave, Suite 1200, Nashville, TN, 37203, USA.
BMC Pulm Med. 2018 Jun 18;18(1):102. doi: 10.1186/s12890-018-0672-y.
Recent research shows that nicotine dependence conveys additional health risks above and beyond smoking behavior. The current study examines whether smoking within 5 min of waking, an indicator of nicotine dependence, is independently associated with asthma outcomes.
Data were drawn from five pooled cross-sectional waves (2005-14) of NHANES, and the final sample consisted of N = 4081 current adult smokers. Weighted logistic regressions were run examining the relationship between smoking within 5 min of waking and outcomes of lifetime asthma, past-year asthma, and having had an asthma attack in the past year. Control variables included demographics, smoking behavior, family history of asthma, depression, obesity, and secondhand smoking exposure.
After adjusting for smoking behavior, smoking within 5 min was associated with an approximately 50% increase in the odds of lifetime asthma (OR = 1.46, p = .008) and past-year asthma (OR = 1.47, p = .024), respectively. After additionally adjusting for demographics and other asthma risk factors, smoking within 5 min of waking was associated with a four-fold increase in the odds of lifetime asthma (OR = 4.05, p = .015).
Smoking within 5 min of waking, an indicator of nicotine dependence, is associated with a significantly increased risk of lifetime asthma in smokers. These findings could be utilized in refining risk assessment of asthma among smokers.
最近的研究表明，尼古丁依赖除了与吸烟行为有关之外，还会带来额外的健康风险。本研究探讨了在醒来后 5 分钟内吸烟（尼古丁依赖的一个指标）是否与哮喘结果独立相关。
数据来自 NHANES 的五个汇总横断面波（2005-14 年），最终样本包括 N=4081 名当前成年吸烟者。使用加权逻辑回归分析了在醒来后 5 分钟内吸烟与终生哮喘、过去一年哮喘以及过去一年有哮喘发作的关系。控制变量包括人口统计学特征、吸烟行为、哮喘家族史、抑郁、肥胖和二手烟暴露。
在调整了吸烟行为后，在醒来后 5 分钟内吸烟与终生哮喘（OR=1.46，p=0.008）和过去一年哮喘（OR=1.47，p=0.024）的几率分别增加了约 50%。在进一步调整了人口统计学特征和其他哮喘危险因素后，在醒来后 5 分钟内吸烟与终生哮喘的几率增加了四倍（OR=4.05，p=0.015）。
在醒来后 5 分钟内吸烟，这是尼古丁依赖的一个指标，与吸烟者终生哮喘的风险显著增加有关。这些发现可用于改进吸烟者哮喘风险评估。
