利用国家电子健康记录数据库的数据对外科丁胺卡那霉素群体药动学模型进行评估。
External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.
机构信息
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
出版信息
Antimicrob Agents Chemother. 2018 Aug 27;62(9). doi: 10.1128/AAC.00669-18. Print 2018 Sep.
Abstract
Gentamicin is a common antibiotic used in neonates and infants. A recently published population pharmacokinetic (PK) model was developed using data from multiple studies, and the objective of our analyses was to evaluate the feasibility of using a national electronic health record (EHR) database for further external evaluation of this model. Our results suggest that, with proper data capture procedures, EHR data can serve as a potential data source for external evaluation of PK models.
摘要
庆大霉素是一种常用于新生儿和婴儿的常用抗生素。最近发表了一个群体药代动力学（PK）模型，该模型使用了来自多项研究的数据。我们分析的目的是评估使用国家电子健康记录（EHR）数据库对该模型进行进一步外部评估的可行性。我们的研究结果表明，通过适当的数据采集程序，EHR 数据可以作为 PK 模型外部评估的潜在数据源。
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