• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.利用国家电子健康记录数据库的数据对外科丁胺卡那霉素群体药动学模型进行评估。
Antimicrob Agents Chemother. 2018 Aug 27;62(9). doi: 10.1128/AAC.00669-18. Print 2018 Sep.
2
Predictive Performance of a Gentamicin Pharmacokinetic Model in Term Neonates with Perinatal Asphyxia Undergoing Controlled Therapeutic Hypothermia.预测性研究：在接受控制性体温治疗的围产期窒息足月新生儿中，庆大霉素药代动力学模型的预测性能。
Ther Drug Monit. 2024 Jun 1;46(3):376-383. doi: 10.1097/FTD.0000000000001166. Epub 2024 Jan 24.
3
Predictive performance of a gentamicin population pharmacokinetic model in neonates receiving full-body hypothermia.庆大霉素群体药代动力学模型在接受全身低温治疗的新生儿中的预测性能。
Ther Drug Monit. 2014 Oct;36(5):584-9. doi: 10.1097/FTD.0000000000000056.
4
Population Pharmacokinetic Modeling of Gentamicin in Pediatrics.儿科患者中庆大霉素的群体药代动力学模型建立。
J Clin Pharmacol. 2019 Dec;59(12):1584-1596. doi: 10.1002/jcph.1479. Epub 2019 Jul 8.
5
A review of population pharmacokinetic models of gentamicin in paediatric patients.氨基糖苷类药物在儿科患者中的群体药代动力学模型研究综述。
J Clin Pharm Ther. 2019 Oct;44(5):659-674. doi: 10.1111/jcpt.12850. Epub 2019 May 17.
6
Clinical audit of gentamicin use by Bayesian pharmacokinetic approach in critically ill children.应用贝叶斯药代动力学方法对危重症患儿庆大霉素使用的临床审核。
J Infect Chemother. 2020 Jun;26(6):540-548. doi: 10.1016/j.jiac.2020.01.007. Epub 2020 Feb 15.
7
A Population Pharmacokinetic Model of Gentamicin in Pediatric Oncology Patients To Facilitate Personalized Dosing.用于促进个体化给药的儿科肿瘤患者庆大霉素群体药代动力学模型
Antimicrob Agents Chemother. 2017 Jul 25;61(8). doi: 10.1128/AAC.00205-17. Print 2017 Aug.
8
Gentamicin pharmacokinetics in preterm infants with a patent and a closed ductus arteriosus.患有开放性和闭合性动脉导管的早产儿的庆大霉素药代动力学
Pharm World Sci. 2001 Oct;23(5):200-4. doi: 10.1023/a:1012490704731.
9
A gentamicin pharmacokinetic population model and once-daily dosing algorithm for neonates.一种用于新生儿的庆大霉素药代动力学群体模型及每日一次给药算法。
Pharmacotherapy. 2003 May;23(5):585-91. doi: 10.1592/phco.23.5.585.32196.
10
Gentamicin pharmacokinetics and dosing in neonates with hypoxic ischemic encephalopathy receiving hypothermia.新生儿缺氧缺血性脑病行低温治疗时的庆大霉素药代动力学和剂量。
Pharmacotherapy. 2013 Jul;33(7):718-26. doi: 10.1002/phar.1263. Epub 2013 Apr 1.

引用本文的文献

1
Can Population Pharmacokinetics of Antibiotics be Extrapolated? Implications of External Evaluations.抗生素群体药代动力学可否外推？外部评估的影响。
Clin Pharmacokinet. 2021 Jan;60(1):53-68. doi: 10.1007/s40262-020-00937-4.
2
Irbesartan Attenuates Gentamicin-induced Nephrotoxicity in Rats through Modulation of Oxidative Stress and Endogenous Antioxidant Capacity.厄贝沙坦通过调节氧化应激和内源性抗氧化能力减轻庆大霉素诱导的大鼠肾毒性。
Int J Prev Med. 2020 Feb 17;11:16. doi: 10.4103/ijpvm.IJPVM_567_18. eCollection 2020.
3
How to Handle Delayed or Missed Doses: A Population Pharmacokinetic Perspective.如何处理漏服或延迟服药：群体药代动力学视角
Eur J Drug Metab Pharmacokinet. 2020 Apr;45(2):163-172. doi: 10.1007/s13318-019-00598-0.
4
A Pharmacoepidemiologic Study of the Safety and Effectiveness of Clindamycin in Infants.克林霉素在婴儿中的安全性和有效性的药物流行病学研究。
Pediatr Infect Dis J. 2020 Mar;39(3):204-210. doi: 10.1097/INF.0000000000002524.
5
Creation of a Multicenter Pediatric Inpatient Data Repository Derived from Electronic Health Records.创建一个源于电子健康记录的多中心儿科住院患者数据资源库。
Appl Clin Inform. 2019 Mar;10(2):307-315. doi: 10.1055/s-0039-1688477. Epub 2019 May 8.

本文引用的文献

1
Use of Population Pharmacokinetics and Electronic Health Records to Assess Piperacillin-Tazobactam Safety in Infants.利用群体药代动力学和电子健康记录评估哌拉西林-他唑巴坦在婴儿中的安全性。
Pediatr Infect Dis J. 2017 Sep;36(9):855-859. doi: 10.1097/INF.0000000000001610.
2
Development and Evaluation of a Gentamicin Pharmacokinetic Model That Facilitates Opportunistic Gentamicin Therapeutic Drug Monitoring in Neonates and Infants.促进新生儿和婴儿机会性庆大霉素治疗药物监测的庆大霉素药代动力学模型的开发与评估。
Antimicrob Agents Chemother. 2016 Jul 22;60(8):4869-77. doi: 10.1128/AAC.00577-16. Print 2016 Aug.
3
Therapeutic Drug Monitoring, Electronic Health Records, and Pharmacokinetic Modeling to Evaluate Sirolimus Drug Exposure-Response Relationships in Renal Transplant Patients.治疗药物监测、电子健康记录和药代动力学建模以评估肾移植患者中西罗莫司的药物暴露-反应关系
Ther Drug Monit. 2016 Oct;38(5):600-6. doi: 10.1097/FTD.0000000000000313.
4
Population pharmacokinetics of gentamicin and dosing optimization for infants.庆大霉素在婴儿群体中的药代动力学及给药方案优化
Antimicrob Agents Chemother. 2015 Jan;59(1):482-9. doi: 10.1128/AAC.03464-14. Epub 2014 Nov 10.
5
Population pharmacokinetic study of gentamicin in a large cohort of premature and term neonates.庆大霉素在大量早产和足月新生儿队列中的群体药代动力学研究。
Br J Clin Pharmacol. 2014 Nov;78(5):1090-101. doi: 10.1111/bcp.12444.
6
Gentamicin pharmacokinetics in neonates undergoing therapeutic hypothermia.新生儿接受治疗性低温时的庆大霉素药代动力学。
Ther Drug Monit. 2013 Apr;35(2):217-22. doi: 10.1097/FTD.0b013e3182834335.
7
Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study.庆大霉素在早产儿和足月儿中的发育药代动力学：一项前瞻性研究的群体建模
Clin Pharmacokinet. 2009;48(4):253-63. doi: 10.2165/00003088-200948040-00003.
8
Therapeutic drug monitoring of aminoglycosides in neonates.新生儿氨基糖苷类药物的治疗药物监测
Clin Pharmacokinet. 2009;48(2):71-88. doi: 10.2165/00003088-200948020-00001.
9
Population pharmacokinetics of gentamicin in premature newborns.庆大霉素在早产儿中的群体药代动力学。
J Antimicrob Chemother. 2006 Aug;58(2):372-9. doi: 10.1093/jac/dkl244. Epub 2006 Jun 16.
10
Newborns and gentamicin--how much and how often?新生儿与庆大霉素——用量多少及用药频率如何？
J Antimicrob Chemother. 2002 Jan;49(1):13-6. doi: 10.1093/jac/49.1.13.

利用国家电子健康记录数据库的数据对外科丁胺卡那霉素群体药动学模型进行评估。

External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.

机构信息

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.

出版信息

Antimicrob Agents Chemother. 2018 Aug 27;62(9). doi: 10.1128/AAC.00669-18. Print 2018 Sep.

DOI:10.1128/AAC.00669-18
PMID:29914947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6125537/
Abstract

Gentamicin is a common antibiotic used in neonates and infants. A recently published population pharmacokinetic (PK) model was developed using data from multiple studies, and the objective of our analyses was to evaluate the feasibility of using a national electronic health record (EHR) database for further external evaluation of this model. Our results suggest that, with proper data capture procedures, EHR data can serve as a potential data source for external evaluation of PK models.

摘要

庆大霉素是一种常用于新生儿和婴儿的常用抗生素。最近发表了一个群体药代动力学（PK）模型，该模型使用了来自多项研究的数据。我们分析的目的是评估使用国家电子健康记录（EHR）数据库对该模型进行进一步外部评估的可行性。我们的研究结果表明，通过适当的数据采集程序，EHR 数据可以作为 PK 模型外部评估的潜在数据源。