把白细胞介素-17F弄走！ - Suppr

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超能文献

Get the IL-17F outta here!

作者信息

Hall Aisling O'Hara, Towne Jennifer E, Plevy Scott E

机构信息

Janssen Immunology Research and Development, Spring House, PA, USA.

Janssen Immunology Research and Development, San Diego, CA, USA.

出版信息

Nat Immunol. 2018 Jul;19(7):648-650. doi: 10.1038/s41590-018-0141-z.

DOI:10.1038/s41590-018-0141-z

PMID:29915294

Abstract

摘要

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Get the IL-17F outta here!把白细胞介素-17F弄走！

Nat Immunol. 2018 Jul;19(7):648-650. doi: 10.1038/s41590-018-0141-z.

Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T cells through modification of the intestinal microbiota.通过改变肠道微生物群，抑制白细胞介素-17F（IL-17F）而不是白细胞介素-17A（IL-17A）可通过诱导 T 细胞来提供对结肠炎的保护。

Nat Immunol. 2018 Jul;19(7):755-765. doi: 10.1038/s41590-018-0134-y. Epub 2018 Jun 18.

Increased IL-17A/IL-17F expression ratio represents the key mucosal T helper/regulatory cell-related gene signature paralleling disease activity in ulcerative colitis.白细胞介素-17A/白细胞介素-17F表达比率升高代表了溃疡性结肠炎中与黏膜辅助性T细胞/调节性细胞相关的关键基因特征，且与疾病活动平行。

J Gastroenterol. 2017 Mar;52(3):315-326. doi: 10.1007/s00535-016-1221-1. Epub 2016 May 13.

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.表达RORγ的Th17细胞通过IL-17A和IL-17F的冗余效应诱导小鼠慢性肠道炎症。

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TH17 cell induction and effects of IL-17A and IL-17F blockade in experimental colitis.实验性结肠炎中 TH17 细胞的诱导及 IL-17A 和 IL-17F 阻断的作用。

Inflamm Bowel Dis. 2013 Jul;19(8):1567-76. doi: 10.1097/MIB.0b013e318286fa1c.

The gut microbiome as a target for regulatory T cell-based immunotherapy: induction of regulatory lymphocytes by oral administration of anti-LPS enriched colostrum alleviates immune mediated colitis.肠道微生物群作为基于调节性T细胞的免疫疗法的靶点：口服富含抗脂多糖初乳诱导调节性淋巴细胞可减轻免疫介导的结肠炎。

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Cutting edge: an IL-17F-CreEYFP reporter mouse allows fate mapping of Th17 cells.前沿：一种IL-17F-CreEYFP报告基因小鼠可用于Th17细胞的命运图谱分析。

J Immunol. 2009 Feb 1;182(3):1237-41. doi: 10.4049/jimmunol.182.3.1237.

Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD.新型Th17细胞因子白细胞介素-17F（IL-17F）在炎症性肠病（IBD）中的作用：活动期克罗恩病患者结肠中IL-17F表达上调及IBD中IL17F基因p.His161Arg多态性分析

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Inflammatory responses induced by interleukin-17 family members in human colonic subepithelial myofibroblasts.白细胞介素-17家族成员在人结肠上皮下肌成纤维细胞中诱导的炎症反应。

J Gastroenterol. 2007 Sep;42(9):746-53. doi: 10.1007/s00535-007-2091-3. Epub 2007 Sep 25.

Publisher Correction: Get the IL-17F outta here!

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