Faculty of Health and Medicine, University of Newcastle HMRI Building, Kookaburra Circuit, New Lambton Heights, NSW, Australia. Australian Gastrointestinal Research Alliance, Newcastle, NSW, Australia. Macquarie University, Sydney, NSW, Australia. Department of Gastroenterology, Princess Alexandria Hospital, Woolloongabba, QLD, Australia. School of Medicine, University of Queensland, St Lucia, QLD, Australia.
Am J Gastroenterol. 2018 Jul;113(7):1036-1044. doi: 10.1038/s41395-018-0095-7. Epub 2018 Jun 19.
OBJECTIVES: Wheat avoidance in the absence of celiac disease (CD) is common but occurrence of concurrent functional gastrointestinal disorders (FGIDs) in this group is uncertain. The aims of this study were to determine the prevalence of self-reported wheat or gluten sensitivity and doctor diagnosed CD in an Australian population, define the associated gastrointestinal (GI) symptoms and FGIDs, and determine the relationship between self-reported wheat sensitivity, demographic and medical factors. METHODS: A total of 3542 people randomly selected from the Australian population returned a mail survey which contained questions on wheat avoidance, GI symptoms, demographic, medical, and lifestyle factors. We defined self-reported wheat sensitivity as people who reported gastrointestinal symptoms on ingestion of wheat based foods, but did not suffer from celiac disease, inflammatory bowel disease or colorectal cancer. Functional dyspepsia (FD) and irritable bowel syndrome (IBS) were diagnosed by Rome III criteria. CD status was self-reported. RESULTS: The prevalence of self-reported wheat sensitivity in this cohort was 14.9% (95% CI 13.7-16.2). The prevalence of CD was 1.2% (95%CI 0.8-1.6). Doctor diagnosed CD was significantly associated with a diagnosis of FD (OR 3.35, 95%CI 1.72-6.52) and IBS (OR 2.28, 95%CI 1.08-4.81). Those with self-reported wheat sensitivity were more likely to report multiple abdominal symptoms (of the 18 assessed) than those without (3.9 symptoms with self-reported wheat sensitivity vs. 1.6 without, p = 0.0001). In a multivariate analysis, self-reported wheat sensitivity was independently associated with IBS (OR 3.55, 95%CI 2.71-4.65) and FD (1.48, 95%CI 1.13-1.94). CONCLUSIONS: Self-reported wheat sensitivity is common, with a prevalence of 14.9% in this cohort. There is a strong association between both celiac disease and self-reported wheat sensitivity, and chronic gastrointestinal symptoms, as well as a diagnosis of FD and IBS.
目的：在不存在乳糜泻 (CD) 的情况下避免食用小麦很常见，但在该人群中同时存在功能性胃肠道疾病 (FGIDs) 的情况尚不确定。本研究的目的是确定在澳大利亚人群中自我报告的小麦或麸质敏感性以及医生诊断的 CD 的患病率，确定相关的胃肠道 (GI) 症状和 FGIDs，并确定自我报告的小麦敏感性与人口统计学和医疗因素之间的关系。
方法：从澳大利亚人群中随机选择了 3542 人返回邮件调查，其中包含有关避免食用小麦、GI 症状、人口统计学、医疗和生活方式因素的问题。我们将自我报告的小麦敏感性定义为报告摄入含小麦食物后胃肠道症状，但未患乳糜泻、炎症性肠病或结直肠癌的人群。功能性消化不良 (FD) 和肠易激综合征 (IBS) 通过罗马 III 标准诊断。CD 状态为自我报告。
结果：本队列中自我报告的小麦敏感性患病率为 14.9%（95%CI 13.7-16.2）。CD 的患病率为 1.2%（95%CI 0.8-1.6）。医生诊断的 CD 与 FD（OR 3.35，95%CI 1.72-6.52）和 IBS（OR 2.28，95%CI 1.08-4.81）的诊断显著相关。与无自我报告小麦敏感性的人相比，报告多种腹部症状（评估的 18 种症状）的人更有可能出现自我报告的小麦敏感性（有自我报告的小麦敏感性的 3.9 种症状，无自我报告的 1.6 种症状，p=0.0001）。在多变量分析中，自我报告的小麦敏感性与 IBS（OR 3.55，95%CI 2.71-4.65）和 FD（1.48，95%CI 1.13-1.94）独立相关。
结论：自我报告的小麦敏感性很常见，本队列中的患病率为 14.9%。乳糜泻和自我报告的小麦敏感性与慢性胃肠道症状以及 FD 和 IBS 的诊断均有很强的关联。
Nutrients. 2018-10-12
World J Gastroenterol. 2015-6-21
Med J Aust. 2017-8-4
Clin Gastroenterol Hepatol. 2015-11
J Neurogastroenterol Motil. 2025-4-30
Nutrients. 2024-12-4
Nutrients. 2024-1-4
Clin Transl Gastroenterol. 2023-12-1
Front Nutr. 2023-7-20
Nutrients. 2022-5-14
Zotero 插件